PATERNALLY-MEDIATED EFFECTS ON REPRODUCTION

从历史上看，研究遗传和环境因素影响 后代的繁殖和随后的发育 以女性为中心。 在对世界进行了长达一年的评估后， 然而，在文献中，需要对男性介导的 生殖结果是明确的。因此，我们从 正在进行的欧洲怀孕和儿童纵向研究 位于英格兰的布里斯托（“ALSPAC”）。在ALSPAC的研究中， 埃文县分娩妇女的伴侣， 英国在1991- 1992年提供了终身职业和有毒接触 历史这些婴儿和他们的父母将被跟踪七天 年我们对父母的职业历史进行了编码， 使用英国标准职业代码，并将自我分类， 在工作中和家中接触过 四项研究正在进行中。首先是调查 父亲职业和/或自我报告的接触与 胎儿生长法罗博士正在用母亲的数据做同样的研究。 父亲和母亲关于他职业的报告之间的一致性 在第三项研究中进行了研究。最后，我们完成了一项研究 为了医疗目的对性腺进行辐射;有一种暗示性的 但胎儿生长没有显著下降。

Historically, research on genetic and environmental factors affecting reproduction and subsequent development of the offspring has been centered on the female. After a year-long assessment of the world literature, however, the need for an epidemiologic study of male-mediated reproductive outcomes was clear. Therefore we have obtained data from the European Longitudinal Study of Pregnancy and Childhood being conducted at Bristol, England ("ALSPAC"). In the ALSPAC study, more than 7,000 partners of women who delivered infants in Avon County, England during 1991-2 provided lifetime occupational and toxic exposure histories. The infants and their parents will be followed for seven years. We have coded occupational histories of both mothers and father, using the British Standard Occupational Codes, and categorized the self- reported exposures on the job and in the home. Four studies are in progress. First is the investigation of the association of paternal occupation and/or self-reported exposure with fetal growth. Dr. Farrow is doing the same study using maternal data. The concordance between father's and mother's report of his occupation is being examined in the third study. Finally, we have completed a study on radiation to the gonads for medical purposes; there was a suggestive but non-significant decrease in fetal growth.