CORE--METHODS FOR PRACTICAL AND ACCURATE ASSESSMENT OF VITAMIN SUPPLEMENT USE

该项目解决了实际和准确评估的需要， 维生素和矿物质补充剂在营养摄入研究中的使用， 疾病 随着最近对抗氧化剂的关注， 强调维生素和矿物质补充剂在慢性病中的作用 预防 流行病学研究通常使用自我管理 调查问卷，收集有关营养补充剂使用情况的信息。 通常情况下，受访者报告的一般类型的复合维生素或 个人营养补充和使用频率。 非常小 注意所获得的补充剂摄入数据的有效性 通过这些简单的自填问卷。 也有了一定 迫切需要评估这些问卷的准确性，部分原因是 与β-胡萝卜素补充剂相关的意外死亡率， 芬兰的化学预防试验 鉴于广泛的可用性和 补充剂的使用，精确测量其使用将是一个重要的 在饮食干预中确保参与者安全的组成部分， 化学预防试验 本研究的主要目的是评估三个有效性 评估营养补充剂摄入量的方法：（1）电话 管理问卷，（2）自我管理问卷，和（3） 面试官根据对补充材料的审查进行评估 瓶. 通过这些方法获得的营养措施将相互关联 与营养素的黄金标准;精确的剂量信息转录 补充标签。 我们还将评估这三个方面的影响 评估补充剂使用的不同方法对 总营养摄入量（饮食加补充剂），因为这是典型的 在饮食和疾病的研究兴趣曝光。 我们建议收集有关维生素和矿物质补充剂使用的信息 117名用户的补充。 我们将通过电话招募社区样本， 并对补充剂使用情况进行电话问卷调查， 参与者从记忆中回答。 我们将向参与者邮寄一个数据包 自我管理的形式，包括一个简短的人口调查问卷， 食物频率调查表和自我管理的补充表格。 我们将邀请参加者到癌症预防研究中心， 质量控制审查完成的问卷，并要求他们 为面试官提供计算机化评估的补充材料 和标签转录。 这项研究将提供重要信息的相对准确性 不同的方法来衡量参与者的补充剂使用， 流行病学研究、饮食干预和化学预防 审判

This project addresses the need for practical and accurate assessment of vitamin and mineral supplement use in studies of nutrient intake and disease. With the recent focus on anti-oxidants, there is increasing emphasis on the role of vitamin and mineral supplements in chronic disease prevention. Epidemiologic studies commonly use self-administered questionnaires to collect information on nutritional supplement use. Typically, the respondent reports the general type of multivitamin or individual nutrient supplement and frequency of use. Remarkably little attention has been paid to the validity of supplement intake data obtained by these simple self-administered questionnaires. There is now some urgency to assess the accuracy of these questionnaires, motivated in part by the unexpected mortality associated with beta-carotene supplements in the Finnish chemoprevention trial. Given the widespread availability and use of supplements, precision in measuring their use will be an important components of assuring participant safety in dietary intervention and chemoprevention trials. The primary aim of this study is to evaluate the validity of three approaches to assessing nutritional supplement intake: (1) a telephone administered questionnaire, (2) a self-administered questionnaire, and (3) an interviewer administered assessment based on review of supplement bottles. Nutrient measures obtained via these methods will be correlated with nutrients from a gold standard; precise dose information transcribed from supplement labels. We will also evaluate the impact of these three different methods of assessing supplement use on misclassification of total nutrient intake (diet plus supplements), since this is typically the exposure of interest in studies of diet and disease. We propose to collect information on vitamin and mineral supplement use from 117 supplement users. We will recruit a community sample by phone, and administer a telephone questionnaire on supplement use asking participants to respond from memory. We will mail participants a packet of self-administered forms, including a short demographic questionnaire, a Food Frequency Questionnaire, and the self-administered supplement form. We will invite participants to the Cancer Prevention Studies Center for quality control review of the completed questionnaires, and ask them to bring supplements for the interviewer administered computerized assessment and label transcription. This research will provide important information on the relative accuracy of different ways to measure supplement use of participants in epidemiologic studies, and dietary intervention and chemoprevention trials.