Polycomb repressive complex 2 regulation of neurogenesis

大量不直接改变基因的过程，会影响胚胎发育和疾病。一组表观遗传蛋白(PRC2)是发育过程中的核心角色。PRC2控制干细胞发育为体内许多不同的细胞和组织。科学家们不知道PRC2是如何调节胚胎或成人干细胞来制造神经元的。在这个项目中，我们建议将沈阳实验室在PRC2生物学方面的专业知识与Szele实验室在成人脑干细胞方面的专业知识结合起来。我们将研究PRC2是如何正常工作的，以及脑损伤后它是如何工作的。我们相信，我们的合作工作将发现干细胞在神经细胞生成中的表观遗传调节，并为干细胞治疗提供新的见解。

A large number of processes that do not directly change genes, "epigenetic mechanisms" affect embryonic development and disease. One set of epigenetic proteins (PRC2) are central players in development. PRC2 controls stem cell development into many different cells and tissues of the body. Scientists do not know how PRC2 regulates embryonic or adult stem cells to make neurons. In this project, we propose to combine the Shen laboratory expertise in PRC2 biology with the Szele laboratory expertise in adult brain stem cells. We will investigate how PRC2 normally works and how it works after brain injury. We believe our collaborative work will discover epigenetic regulation of stem cells in nerve cell generation, and provide novel insights into stem cell therapy.