Developing diagnostics and therapeutics for preeclampsia: targeting a novel placental specific sFlt-1 variant

先兆子痫是一种可怕的妊娠期疾病，在全球范围内导致数千名母亲和婴儿死亡。它是由一种名为sflt-1的蛋白质从胎盘泄漏并攻击母亲的器官引起的。最近，一种新的sFlt-1亚型被发现，该亚型是针对胎盘的。这可能是导致子痫前期产生毒素的关键疾病。我们将以这种胎盘特异性sflt-1为靶点，产生诊断方法来预测先兆子痫，并探索新的方法来阻断sflt-1的毒性效应，作为开发药物的策略。

Preeclampsia is a dreaded disease of pregnancy, globally responsible for thousands of deaths of mothers and babies. It is caused by a protein called sFlt-1 leaking out of the placenta and attacking the mothers organs. Recently, a new sflt-1 subtype was discovered that is specific to the placenta. It may be the key disease causing toxin in preeclampsia. We will target this placental specific sFlt-1 to generate diagnostics to predict preeclampsia, and explore novel ways to block the toxic effects of sFlt-1 as a strategy to develop drugs.