ACTG 282

这项研究的目的是确定人类活动的分布 阿尔茨海默病患者载脂蛋白E等位基因的研究 和健康的老年人，可能的种族差异的分布 APO-E等位基因，并评估神经病理和 阿尔茨海默病的临床变异性和下降率是由APO- E等位基因。此外，我们希望建立一个DNA库来进行检测 AD的可能标记物。 自1996年2月恢复支持以来，为 所有活体受试者继续从白细胞中提取DNA 参与霍普金斯阿尔茨海默病研究中心(ADRC)。 其余提取的DNA被储存起来，以供未来研究。DNA来自 从冰冻固定的脑组织中提取死亡受试者。一个 自6月获得资助以来，共对161个样本进行了分型 1994年。在上一个供资期间(1995年12月L至1996年11月30日)，共有 23名参与者中有23人已经进行了基因分型。在这13个女人和10个女人中 都是男人。载脂蛋白E基因分型的最终结果，种族 差异以及临床和神经病理相关性将是 随着整个队列的打字工作完成，将于1997年提供。

The purpose of this study is to determine the distribution of the Apolipoprotein E (APO-E) alleles in Alzheimer's disease (AD) patients and healthy elderly, the possible ethnic variations in the distribution of the APO-E alleles and to assess whether neuropathological and clinical variability and rate of decline in AD are accounted for by APO- E genotype. In addition we wish to establish a DNA bank for the testing of possible markers of AD. Since support was renewed in February 1996, collection of blood for the extraction of DNA from WBC's continued in all the live subjects participating in the Hopkins Alzheimer's Disease Research Center (ADRC). The remaining extracted DNA is stored for future studies. DNA from deceased subjects was extracted from frozen and fixed brain tissue. A total of 161 samples have been typed since funding was granted in June 1994. In the last funding period (12/l/95 through 11/30/96), a total of 23 participants have been genotyped. Of these 13 where women and 10 were men. Final results on prevalence of the Apo-E genotypes, racial differences and clinical and neuropathological correlations will be available in 1997 with completion of the typing of the entire cohort.