GEOMETRIC MAPPING OF TISSUE HEART VALVES

生物组织心脏瓣膜的长期（10年以上）耐久性部分取决于设计最佳瓣叶几何结构，最大限度地减少拉伸和屈曲应力集中和磨损。最佳情况下，瓣膜的设计和制造应在生理压力和流量条件下具有相同的瓣叶应力和应变率。这在目前是不可能的，主要原因是缺乏准确的定量几何绘图系统。Vision公司建议调整其DMEyes地形图系统，以绘制组织心脏瓣膜。Vision Inc.的DMEyes使用机器视觉系统，旨在保持广泛材料的映射精度。地形图直接从三维笛卡尔坐标（X、Y和Z数据点）数据阵列获得。测量是基于主射线三角测量的原理。校准的光图案被投射到心脏瓣膜上并由摄像机成像。校准点的位置用于从投影主光线和成像主光线的交点确定表面的形状。对曲面的形状没有任何假设。拟定商业应用：针对心脏瓣膜标测优化的Vision ® DMEyes组织地形图仪预计将由参与组织和生物材料心脏瓣膜开发和设计的研究人员和生物工程师以及制造和质量保证工程师用于制造的组织心脏瓣膜的过程中测试。其他组织标测应用，使用密切相关的DMEyes技术，预计将遵循心脏瓣膜标测应用。

The long term (10 year plus) durability of biological tissue heart valves depends in part on designing optimal leaflet geometry which minimizes tensile and flexion stress concentrations and abrasion. Optimally, the valve should be designed and manufactured with identical leaflet stress and strain rates under physiological pressure and flow conditions from unit to unit. This is currently not possible, due, primarily, to the lack of an accurate quantitative geometric mapping system. Vision Metrics proposes to adapt its DMEyes topographic mapping system to mapping tissue heart valves. Vision Metrics, Inc.'s DMEyes uses a machine vision system designed to maintain mapping accuracy for a wide range of materials. Topographic maps are directly obtained from a three dimensional Cartesian coordinate (X, Y, and Z data points) data array. Measurements are based on the principle of chief ray triangulation. A calibrated light pattern is projected onto the heart valve and imaged by a video camera. The locations of the calibrated points are used to determine the shape of the surface from the intersections of the projected chief rays and the imaged chief rays. No assumptions are made about the shape of the surface. PROPOSED COMMERCIAL APPLICATION: A Vision Metrics DMEyes tissue topographer optimized for heart valve mapping is expected to be used by researchers and bioengineers involved with the development and design of tissue and biomaterial heart valves and by manufacturing and quality assurance engineers for in process testing of manufactured tissue heart valves. Other tissue mapping applications, using closely related DMEyes technology, are expected to follow from the heart valve mapping application.