VAGAL AFFERENTS--SENSATIONS ARISING FROM THE LUNG

描述(改编自申请人的摘要)：本提案重点 从肺部产生的感觉。由电引起的感觉 迷走神经刺激迷走神经的刺激，由各种刺激引起 清醒人类的肺或单个肺段和肺叶将是 检查过了。对肺施加各种刺激所产生的感觉 包括支气管收缩和局限性肺叶或肺段充气 在正常受试者、有肺衰竭的受试者 失神经肺(肺移植后)和患有 去神经胸壁(高位颈髓横断术)。这个 拟议的实验解决了几个问题：(A) 感觉来自肺的传入，(B)哪种类型的肺 传入神经负责各种感觉，(C)与肺有关 感觉很好地局限于肺区，(D)什么是可感知的 适用于肺传入的各种刺激的阈值。特指 将确定以下内容：1)呼吸系统感觉由什么引起 电刺激清醒人类的迷走神经，2)是否 感觉到与支气管收缩有关的“紧迫感” 有失神经肺的受试者，3)感觉是否产生于 局部麻醉或局部麻醉可消除肺叶或节段性肺膨胀 肺的失神经，4)局灶性塌陷引起的感觉 肺段。迷走神经传入被认为是 呼吸困难和其他由肺部引起的呼吸系统感觉。 这些研究有望增加对这些特性的理解 改善呼吸系统疾病的诊断和治疗 心肺疾病。

DESCRIPTION (Adapted from the applicant's abstract): This proposal focuses on sensations arising from the lung. Sensations arising from electrical stimulation of the vagus nerve and resulting from various stimuli applied to the lungs or individual lung segments and lobes in awake humans will be examined. Sensations resulting from various stimuli applied to the lung including bronchoconstriction and localized lobar or segment lung inflation and lung collapse will be performed in normal subjects, subjects with denervated lungs (following lung transplantation) and subjects with denervated chest walls (high cervical spinal cord transection). The proposed experiments address several questions: (a) what qualities of sensations arise from pulmonary afferents, (b) which types of pulmonary afferents are responsible for various sensations, (c) are pulmonary sensations well localized to lung regions, (d) what are the perceptible thresholds of various stimuli applied to pulmonary afferents. Specifically the following will be determined: 1) what respiratory sensations arise from electrical stimulation of the vagus nerve in awake humans, 2) whether the sensations of "tightness" associated with bronchoconstriction is perceived by subjects with denervated lungs, 3) whether the sensations produced by lobar or segmented lung inflation is abolished by topical anesthesia or denervation of the lungs, 4) what sensations arise from focal collapse of lung segments. Vagal afferents are proposed to be the source of breathlessness and other respiratory sensations arising from the lung. These studies are expected to increase the understanding of the properties of respiratory sensation and improve the diagnosis and management of cardiopulmonary disease.