STRUCTURE BASED VISUAL ACCESS TO BIOMEDICAL INFORMATION

描述(摘自应用程序摘要)： 本方案所描述的工作是开发在线组合的空间和 表示、存储、检索和可视化的符号方法 解剖学信息，既是理解人类生物学的一种手段 结构，并作为进入快速增长的 生物医学中基于文本的在线信息源。在这份提案中，我们 将解决组合空间所涉及的一些基本问题 和符号解剖信息，并将测试这些问题的解决方案 基于万维网的胸部三维解剖信息系统 内脏。临床医生、研究人员和学生将能够使用这一技术 系统来检索特定的解剖学知识，其形式为 动态生成的交互式3-D场景和相应的符号 信息，无需查阅硬拷贝地图集或导航 通过不相关的基于计算机的图像在找到所需的 信息。为了建立这个系统，我们需要解决以下问题 空间建模中的基本问题，这些模型在 基于知识的空间数据库系统，并通过 在线用户界面和空间查询处理器。具体目标是 这项建议是：1)开发一个知识库，组织和 集成解剖的空间和符号模型，2)实现解剖 基于知识的空间与符号相结合的信息系统 利用动态生成的3-D场景进行检索，3)开发用于 流畅地渲染并实时与场景交互，以及4) 通过集成其他空间数据并将其提供给 解剖医学生和放射治疗规划师。成就 这些目的将导致一个有用的信息系统，用于解剖 胸部内脏可以通过高技术等新技术来增强 性能图形和虚拟现实。此外，这些信息 我们在这个项目中建立的框架和方法将是可推广的 只是对身体不同部位和不同部位的大体解剖 解剖学数据库，还用于结构信息的管理 与细胞和分子生物学以及发育和分子生物学有关的 神经生物学。

DESCRIPTION (Taken from application abstract): The long term goal of the work described in this proposal is to develop on-line combined spatial and symbolic methods for representing, storing, retrieving and visualizing anatomical information, both as a means for understanding human biological structure, and as a visual gateway into the rapidly increasing array of on-line text-based information sources in biomedicine. In this proposal we will address some of the fundamental problems involved in combining spatial and symbolic anatomic information, and will test solutions to these problems in a World Wide Web based 3-D anatomy information system for the thoracic viscera. Clinicians, researchers and students will be able to use this system to retrieve specific anatomic knowledge, in the form of dynamically-generated interactive 3-D scenes and corresponding symbolic information, without the need to consult hard copy atlases or to navigate through irrelevant computer-based images before finding the needed information. In order to build this system we will need to address fundamental problems in spatial modeling, organization of these models in a knowledge based spatial database system, and access to the models via an on-line user interface and spatial query processor. The specific aims for this proposal are: 1) develop a knowledge base that organizes and integrates spatial and symbolic models of anatomy, 2) implement an anatomy information system that combines knowledge-based spatial and symbolic retrieval with dynamically generated 3-D scenes, 3) develop methods for smoothly rendering and interacting with the scene in real-time, and 4) evaluate the system by integrating other spatial data and by providing it to anatomy medical students and radiation treatment planners. Accomplishment of these aims will lead to a useful information system for the anatomy of the thoracic viscera that can be enhanced with new technology such as high performance graphics and virtual reality. Moreover, the information framework and methods we establish in this project will be generalizable not only to gross anatomy in different regions of the body and to different anatomical databases, but also to the management of structural information pertaining to cellular and molecular biology, as well as developmental and neurobiology.