Developing and testing pro-thrombotic conjugates for brain AVMs

脑血管异常破裂会导致儿童和年轻人中风。在这个项目中，我们将测试堵塞异常血管的新方法。我们首先使用辐射来诱导血管的变化，然后针对这些变化来闭塞血管。成功的治疗需要结合靶向和凝块形成剂。在这个项目中，我们将测试靶向和凝血剂的组合。最有效的组合将进展到临床试验。

Rupture of brain blood vessel abnormalities causes stroke in children and young adults. In this project, we will test new methods for occluding abnormal vessels. We use radiation first to induce changes in the vessels, and then target those changes to occlude the vessels. Successful treatment requires combining targeting and clot forming agents. In this project we will test combinations of targeting and clotting agents. The most effective combination will be progressed towards clinical trials.