MICA: Investigating the role of myeloperoxidase as a key mediator of renal damage in crescentic glomerulonephritis and reno-cardiac disease

我们认为，白细胞用来抵御微生物的一种蛋白质，称为髓过氧化物酶，似乎是在各种情况下导致肾脏损伤的关键介质，例如血管炎和狼疮，它可以影响肾脏，还参与促进动脉加速老化，这可能导致患有自身免疫性疾病（如血管炎和狼疮）的患者患严重的心脏病。有趣的是，髓过氧化物酶可以被抑制，显然没有不良影响。我们希望测试它是否是一个可行的药物靶点，通过研究骨髓过氧化物酶阻滞剂是否可以用于保护肾脏免受各种疾病的损害，这些疾病导致肾脏炎症并导致肾衰竭，以及由于其在引起动脉损伤方面的不同作用，它们是否也可以保护这些患者免于加速心脏病。

We believe that a protein used by white blood cells to defend against microbes, called myeloperoxidase, appears to be the critical mediator in causing kidney damage in various conditions, such as vasculitis and lupus that can affect the kidneys, and is also involved in promoting accelerated furring of the arteries, that can lead to significant heart disease in patients with autoimmune diseases such as vasculitis and lupus. Interestingly, myeloperoxidase can be inhibited, apparently without ill effect. We wish to test if it is a viable drug target, by investigating whether myleoperoxidase blockers could be used to protect the kidney from damage in various disorders which lead to kidney inflammation and result in kidney failure and whether, because of its diverse roles in causing arterial damage, they may also protect from the accelerated heart disease that can be found in such patients.