TOURETTES DISORDER IN CHILDREN--PROSPECTIVE FOLLOWUP

描述(改编自申请人摘要)：这是一份申请 导师临床科学家发展奖(K08)。申请人是一名 有经验的临床医生将职业重点从临床工作和医疗转移 从教育到临床研究。申请者的主要目标是追求 专注于临床问题的临床研究生涯 练习一下。在过去的两年里，作为新成立的 马萨诸塞州联合总医院-麦克莱恩儿科医院 精神药理学项目，约瑟夫·比德曼博士，主任，申请人 越来越多地参与临床驱动的程序性研究 专注于多发性抽动症。然而，缺乏正式的研究 培训和投入研究活动的时间是认真的 在实现独立的目标方面取得快速进展的障碍 调查员。允许申请者将全部时间集中在 获得成为独立调查人员所需的工具，这 奖励将允许申请者实现这些目标。 在获奖期间，申请者将全面发展 临床研究方法技能，特别注重纵向研究 专业研究。这将涉及以下方面的培训： 1)接触临床研究(10%的努力)，包括儿科 精神药理学、遗传学、流行病学、纵向随访研究 ADHD的儿科精神药理学方案及纵向研究 以及相关的疾病。此外，她将继续她的工作与 Jenike博士关于多发性抽动症比较现象学的研究小组 以及强迫症和神经成像。2)正式说教 培训(20%的努力)这部分培训将允许 申请人须继续进修研究方法及 技巧。这将包括课程作业(详细说明如下)和以下网址的教程 哈佛大学公共卫生学院生物统计学和流行病学。(10 努力百分比)申请者将由Nan Laird博士指导， 哈佛大学公共卫生学院生物统计系， 纵向设计的统计方法(10%努力)。3) 接触已建立的国家TS研究计划(5%的努力)： 申请人将每月与James Leckman博士( 和David Pauls(遗传学副教授) 儿童研究中心关于TS的方法学方法，包括发展 精神病理学、临床评估和家庭研究。4)暴露于 基础神经科学(5%努力)：申请者将每月与 安妮·杨，医学博士，马萨诸塞州神经病学服务主席 和一位国际知名的神经学家 对运动障碍和多发性抽动障碍的长期兴趣 回顾与多发性抽动症相关的基本神经科学问题。5) 候选人指导的研究研究(40%努力)申请者 提出了一项针对150个汉字的系统特征和类型学的研究 患有多发性抽动症的儿童和青少年，然后将被跟踪 预计将超过四年。50名年龄、性别和性别的对比样本 将对与之匹配的非抽动症精神病对照进行系统评估 在同一时期紧随其后。这项研究将受到监督和指导 比德曼医生写的。

DESCRIPTION (Adapted from applicant's abstract): This is an application for a Mentored Clinical Scientist Development Award (K08). The Applicant is an accomplished clinician shifting career focus from clinical work and medical education to clinical research. The applicant's primary goal is to pursue a career in clinical research focusing on questions driven by clinical practice. Over the last two years, as a staff member of the newly formed Joint Massachusetts General Hospitals-McLean Hospital Pediatric Psychopharmacology Program, Dr. Joseph Biederman, Director, the applicant has become increasingly involved in clinically-driven, programmatic research focused on Tourette's Disorder. However, the absence of formal research training and time to devote to research activities have been serious impediments for rapid progress toward the goal of becoming an independent investigator. By permitting the full focus of the applicant's time on achieving the necessary tools to become an independent investigator, this Award will allow the applicant to achieve these goals. During the period of the Award the applicant will develop comprehensive skills in clinical research methodology with a special focus on longitudinal pros-pective studies. This will involve training in the following areas: 1) Exposure to Clinical Research (10 percent effort) including pediatric psychopharmacology, genetics, epidemiology, longitudinal follow-up studies on pediatric psychopharmacology protocols and longitudinal studies of ADHD and related disorders. In addition, she will continue her work with Dr.Jenike's group on the comparative phenomenology of Tourette's Disorder and Obsessive-Compulsive Disorder and neuroimaging. 2) Formal Didactic Training (20 percent effort) This part of the training will allow the applicant to pursue further education in research methodology and techniques. This will include course-work (detailed below) and tutorials at the Harvard School of Public Health in biostatistics and epidemiology. (10 percent effort) The applicant will be tutored by Dr. Nan Laird, Chairman of the Department of Biostatistics at the Harvard School of Public Health, on statistical methods of longitudinal designs (10 percent effort). 3) Exposure to an Established National TS Research Program (5 percent effort): The applicant will meet monthly with Drs. James Leckman (Professor of Psychiatry) and David Pauls (Associate Professor of Genetics) at the Yale Child Study Center on methodologic approaches to TS, including developmental psychopathology, clinical assess-ment, and family studies. 4) Exposure to Basic Neuroscience (5 percent effort): The applicant will meet monthly with Anne Young, M.D., Ph.D., Chairman of the Neurology Service at Massachusetts General Hospital, and an internationally known neuroscientist with longstanding interest in movement disorders and Tourette's Disorder, to review basic neuroscience issues related to Tourette's Disorder. 5) The Candidate's Mentored Research Study (40 percent effort) The applicant proposes a study aimed at systematic character-ization and typology of 150 children and adolescents with Tourette's disorder who will then be followed prospectively over four years. A comparison sample of 50 age, gender and SES matched non-tic psychiatric controls will be assessed and systematically followed over the same period. This study will be supervised and mentored by Dr. Biederman.