TESTS OF COGNITION IN SLEEP DISORDERS BY ERP, RT & EEG

提出了一种结合三种不同技术来评估日间过度嗜睡患者的认知功能的系统。通过事件相关电位、警觉测试中的行为测量和多导睡眠图来评估患者的状态。听觉古怪任务期间的事件相关电位记录提供了认知处理速度和患者在任务中的注意力/动机参与程度的客观测量。对目标音的时序按钮按下反应提供了处理速度的行为测量，包括运动和认知成分。遗漏和委员会回应错误索引注意力疏忽。警戒减退是通过比较上半场和下半场进行评估的。脑电测量，如阿尔法和西塔功率，将进一步指示患者在任务过程中的状态。除了睡眠实验室应用外，该设备的便携式版本将在患者家中提供测试功能。对于阻塞性睡眠呼吸暂停综合症患者，这些测试可以由家庭护理技术人员在CPAP治疗中探访患者来实施，以跟踪进展、监测依从性并调整设备参数。这一新的诊断工具将用于跟踪睡眠障碍患者认知障碍的治疗效果。拟议的商业应用：该系统将为评估睡眠障碍患者的认知状态提供一种新的、创新的和有效的诊断工具，无论是在实验室还是在家里。它将以便携式版本作为独立设备提供，并作为数字多导睡眠图和诱发电位系统的选项提供。它将被销售给睡眠实验室用于临床，也用于研究日间过度嗜睡和/或事件相关电位。

A system is proposed that combines three different techniques to assess the cognitive functions of patients with excessive daytime sleepiness. The patient's state is assessed by Event Related Potentials, behavioral measures from a vigilance test, and polysomnography. ERP recordings during an auditory oddball task provide objective measures of the speed of cognitive processing and the patient's degree of attentional/motivational involvement in the task. Timing button press responses to target tones provide a behavioral measure of processing speed, including motor as well as cognitive components. Omission and commission response errors index attention lapses. Vigilance decrement is assessed by comparing the first and second halves of the session. EEG measures, such as alpha and theta power, will further index patient state over the course of the task. In addition to sleep laboratory applications, a portable version of the device will provide testing capabilities at the home of the patient. For OSA patients, these tests can be administered by home care technicians visiting the patient on CPAP therapy to follow up progress, monitor compliance, and adjust equipment parameters. This new diagnostic tool will be used to follow the effect of treatment on cognitive impairment in sleep disorders. PROPOSED COMMERCIAL APPLICATIONS: This system will provide a new, innovative and effective diagnostic tool for the assessment of cognitive states of patients with sleep disorders, in the laboratory and at home. It will be offered in a portable version as a stand- alone unit and as an option on digital polysomnography and Evoked Potential systems. It will be marketed to sleep laboratories for clinical use, and also for research applications on Excessive Daytime Sleepiness and/or Event Related Potentials.