INORGANIC ION EXCHANGER FOR USE IN 82SR/82RB SEPARATIONS

82Rb广泛用于心血管研究的正电子发射断层扫描（PET），它是由82Sr衰变产生的。82Sr是由铷或钼靶的辐照产生，然后用离子交换技术提取82Sr。目前使用有机离子交换树脂的分离方法速度慢，导致产品价格昂贵。相比之下，由于非钛酸钠对锶具有极高的选择性，并且产品收率更高，因此可以实现更快的分离，从而降低同位素成本，从而降低PET扫描成本。非钛酸钠也更耐辐射损伤，消除了可能的热原释放，并且可以重复使用，最大限度地减少废物的产生。非钛酸钠也将被评估用于82Rb/82Sr发生器，作为目前离子交换器的替代品。锶的高选择性将使82Rb洗脱过程中有毒的82Sr和85Sr释放到体内的程度降到最低，从而减少对人体组织的辐射损伤。第二阶段将与洛斯阿拉莫斯国家实验室放射性同位素研究部的人员合作进行，使用实际的82Sr目标解决方案，以确保开发的方法直接适用于最终用户的需求。拟议的商业应用：本研究适用于辐照靶中82sr的分离和纯化，以及82Rb发生器的设计和运行。非钛酸钠的使用将改善获得82Sr的工艺，从而降低最终产品的成本。通过降低82Rb洗脱过程中释放的有害R2Sr水平，发生器性能的改进将使医务人员和PET患者受益。该技术也可以应用于其他锶同位素的纯化，用于医疗用途。

82Rb is used extensively in Positron Emission Tomography (PET) for cardiovascular studies and is generated from the decay of 82Sr. 82Sr is produced by the irradiation of rubidium or molybdenum targets followed by the extraction of 82Sr using ion exchange techniques. Current separation methods using organic ion exchange resins are slow leading to an expensive product. By contrast sodium nonatitanate enables a more rapid separation to be achieved, due to it's exceptionally high selectivity for strontium, and a higher product yield, leading to lower isotope costs and consequently a reduction in the cost of PET scans. Sodium nonatitanate is also far more resistant to radiation damage, eliminating possible pyrogen releases, and can be used repeatedly, minimizing waste generation. Sodium nonatitanate will also be evaluated for use in 82Rb/82Sr generators as a replacement for current ion exchangers. The high strontium selectivity will result in less radiation damage to body tissues by minimizing the release of toxic 82Sr and 85Sr into the body during elution of 82Rb. Phase II will be performed in partnership with personnel at the Radioisotope Research section at Los Alamos National Laboratory using actual 82Sr target solutions to ensure the methodology developed is directly applicable to the needs of the end user. PROPOSED COMMERCIAL APPLICATION: The research is applicable to the separation and purification of82Sr from irradiated targets and in the design and operation of 82Rb generators. The use of sodium nonatitanate will improve the process for obtaining 82Sr, resulting in a reduced cost of the final product. Improvements to generator performance will benefit medical personnel and PET patients by reducing the levels of harmful R2Sr released during elution of 82Rb. The technology developed n)ay also be applied to the purification of other strontium isotopes for medicinal applications.