UTERINE PAIN--MECHANISMS AND MODULATION

描述：这项研究的长期目标是阐明 盆腔疼痛的病理生理机制研究进展 缓解女性和男性盆腔疼痛综合征的策略 病人。慢性非恶性和恶性盆腔疼痛综合征是一种 临床医生面临的主要挑战和治疗策略，包括 内科和外科手术的方法往往都不成功。这个 骨盆疼痛的神经解剖学和神经生理学机制是 人们对此知之甚少。动物模型的使用是 了解潜在的神经生理学和神经药理学 骨盆疼痛的机制。我们目前的研究目标是发展 使用大鼠建立子宫疼痛的动物模型，(1)获取详细的 有关处理伤害性传入的脊髓通路的信息 来自子宫的输入，(2)评估外周阿片类药物的影响 子宫伤害性输入在脊髓加工中的应用 (3)测定发情周期对脊髓的影响 子宫伤害性刺激的炮制及其药理作用 操纵。具体目标1是描述行为 伤害性扩张、炎症引起的宫痛的表现 或者是脑缺血。具体目标2是识别脊柱节段和椎板 在这些处理伤害性传入输入的片段中 子宫。这些数据本身很重要，也将提供 部分药理研究的解剖学基础。具体目标3是 检测脊髓背角神经元的神经生理特性 对有害的子宫刺激有反应。对这些的理解 特征将是未来药物干预的基础 以减轻子宫疼痛。具体目标4是回答 问题：阿片类药物对脊髓的外周影响是什么？ 处理有害的子宫刺激？新近外源性阿片类药物 激动剂已被证明有止痛作用，当在 周围神经末梢附近。这一点已经在 动物模型以及躯体疼痛的患者；然而，没有数据显示 有关于子宫疼痛的信息。这些研究应该是基本的新的 关于神经解剖学和神经生理学机制的信息 子宫疼痛的症状。这是第一次尝试研究 外周应用阿片类药物调节子宫疼痛的处理。这个 这些实验的结果可能会迅速有助于 治疗子宫疼痛综合征的新药理学方法。

DESCRIPTION: The long range objective of this research is to elucidate the pathophysiological mechanisms of pelvic pain in order to develop better strategies for alleviating pelvic pain syndromes in female and male patients. Chronic non-malignant and malignant pelvic pain syndromes are a major challenge to the clinician, and treatment strategies, including medical and surgical approaches, are often unsuccessful. The neuroanatomical and neurophysiological mechanisms underlying pelvic pain are poorly understood. The use of animal models is a necessary step in understanding the underlying neurophysiological and neuropharmacological mechanisms of pelvic pain. Our goals in the present studies are to develop an animal model of uterine pain using the rat, (1) to obtain detailed information about the spinal pathways that process nociceptive afferent input from the uterus, (2) to assess the effects of peripheral opioid application on the spinal processing of nociceptive input from the uterus, (3) to determine the influence of the estrous cycle on the spinal cord processing of noxious uterine stimulation and its pharmacological manipulation. Specific aim 1 is to characterize the behavioral manifestations of uterine pain induced by noxious distension, inflammation or ischemia. Specific aim 2 is to identify the spinal segments and laminae within these segments which process nociceptive afferent input from the uterus. These data, important in themselves, will also provide the anatomical basis for part of the pharmacological studies. Specific aim 3 is to examine the neurophysiological characteristics of dorsal horn neurons that respond to noxious uterine stimulation. The understanding of these characteristics will be the basis for future pharmacological interventions to alleviate pain from the uterus. Specific aim 4 is to answer the question, what are the peripheral effects of opioids on the spinal cord processing of noxious uterine stimulation? Recent, exogenous opioid agonists have been shown to have analgesic effects when administered in the vicinity of peripheral nerve terminals. This has been demonstrated in animal models as well as in patients with somatic pain; however, no data are available regarding uterine pain. These studies should fundamental new information concerning the neuroanatomical and neurophysiological mechanisms of uterine pain. They are the first studies attempting to examine whether peripherally applied opioids modulate the processing of uterine pain. The results of these experiments may rapidly contribute to the development of new pharmacological approaches to treat uterine pain syndromes.