GENETIC LINKAGE STUDY IN PARKINSONS DISEASE

描述(改编自调查者摘要)原因 特发性帕金森氏病(PD)是一种使人衰弱的疾病， 据估计，60岁或以上的人中有1%仍然未知。研究 由与该项目有关的调查人员和其他人 家族性因素在帕金森病发病风险中有重要作用。这 该提案是对美国国家广播公司的一项计划公告的回应 神经疾病和中风研究所，要求研究 帕金森氏症病因中可能的遗传因素。的目标是 这个项目是开始连锁研究，以定位易患帕金森病的基因 风险。 为了确定基因组中包含与帕金森病风险相关的基因的区域， 研究人员建议在400年内进行10厘米密度的基因组扫描。 受影响的兄弟姐妹对。参赛者将通过 10个附属临床站点的多机构协作。400人 受影响的同胞对将包括两组，每组200对。基因组 扫描将分别在每组200人中进行，第二组 为追求有希望的联系和复制提供一种机制 在第一组中发现了显著的联系。调查人员将评估 可能的遗传异质性与发病年龄、帕金森病相关 家族史和危险因素的参与。

DESCRIPTION (Adapted from the Investigator's Abstract) The cause of Idiopathic Parkinson's disease (PD), a debilitating disease that afflicts an estimated 1 percent of persons age 60 or older, remains unknown. Research by investigators affiliated with this project and by others have demonstrated a significant familial component in the risk for PD. This proposal is in response to a Program Announcement from the National Institute of Neurological Disorders and Stroke, requesting research into possible genetic factors in the cause of Parkinson's disease. The goal of this project is to begin linkage studies to map genes which predispose to PD risk. To identify regions of the genome containing genes associated with PD risk, the investigators propose a 10 centimorgan density genome scan in 400 affected sibling pairs. Participants will be recruited through a multi-institutional collaboration of ten affiliated clinical sites. The 400 affected sib pairs will consist of two sets of 200 pairs each. The genome scan will be done separately in each set of 200, with the second set providing a mechanism for pursuing promising linkages and replicating significant linkages found in the first set. The investigators will assess possible genetic heterogeneity associated with variation in age at onset, PD family history, and risk factor involvement.