STARTLE PLASTICITY

精神分裂症、强迫症和 多发性抽动症的部分原因是感觉运动门控缺陷。 被诊断为这些疾病的患者脉搏前缺乏 抑制(PPI)(感觉运动门控的衡量标准)。另外， 精神分裂症患者有惊人的居住缺陷。5-羟色胺 系统在病理生理学和发病机制上都有牵连。 这些疾病的治疗方法的作用。更好地理解 调节PPI和居住的神经机制(两种形式 惊吓可塑性)可以开发出更好的治疗方法。 该项目建议研究突触前和突触后的作用 脑内5-羟色胺-1B受体和特异性神经回路 调节PPI和习惯化。5-HT1B受体调节活性 多巴胺、5-羟色胺和GABA神经元已经被证明 调制PPI。

The symptoms of schizophrenia, obsessive-compulsive disorder (OCD), and Tourette's syndrome result in part from sensorimotor gating deficits. Patients diagnosed with these disorders have deficient prepulse inhibition (PPI) (a measure of sensorimotor gating). Additionally, schizophrenia patients have startle habitation deficits. The serotonin system has been implicated in both the pathophysiology and the mechanism of action of therapeutics for these disorders. A better understanding of the neural mechanisms that modulate PPI and habitation (two forms of startle plasticity) could permit the development of better treatments. This project proposes to investigate the role of pre- and postsynaptic serotonin-1B (5-HT1B) receptors and specific neural circuits in modulating PPI and habituation. 5-HT1B receptors regulate the activity of dopamine, serotonin, and GABA neurons that have been shown to modulate PPI.