EFFECTS OF ORAL AND SYSTEMIC DISEASE ON QUALITY OF LIFE

只有当实施“下游”干预措施来控制炎症，从而改善患者和人群的健康时，炎症疾病中心的基本生物学发现的最终价值才会变得明显。在这方面，人类健康包括延长寿命和提高生活质量-《健康人民2000》倡议中所载的保健系统的两个目标。然而，直到最近，可靠和有效的方法来衡量口腔健康相关的生活质量已成为广泛使用，其结果是，口腔健康干预措施的生活质量结果的评估方法仍然处于起步阶段。对该中心的使命很重要的一个领域是局部（口腔）和全身性疾病对人类健康的潜在协同效应，尽管缺乏方法学工作来评估这种联合效应与疾病特异性（即，口腔健康相关QoL）或通用QoL仪器。本研究的目的是评估方法，是最佳的测量联合和协同作用对全身条件，口腔疾病及其治疗的生活质量。本研究将使用口腔健康影响简档（OHIP-14）测量口腔健康相关QoL，并使用医学结局研究简档健康调查（SF-36）测量遗传QoL。这些调查问卷将由130名（终末牙列）患有晚期牙病并表示有意最终拔除这些牙齿并放置全口义齿的患者完成。将在基线、第4周、第26周和第52周进行QoL测量，并从治疗记录中提取同期治疗和临床状态。将对数据进行口腔和一般QoL的心理测量独立性分析。最初将通过横断面分析探索具体目标，其中QoL指标将是因变量，口腔状态（目标1）或牙科治疗（目标2）将是因变量。我们的研究假设将使用纵向数据进行分析，这些数据使用重复的方差测量进行分析。

The ultimate value of fundamental biological discoveries from the Center for Inflammatory Disorders will become apparent only when "downstream" interventions are implemented to control inflammation, thereby improving the health of patients and population. In this context, human health includes both extension of lifespan and enhancement of Quality of Life (QoL)-two objectives of the health care system enshrined in the Healthy People 2000 initiative. However, it is only recently that reliable and valid methods for measuring oral health related QoL have become widely available, with the consequence that methods for evaluate quality of life outcomes from oral health interventions remain in their infancy. One area that is important to this Center's mission is the potential for synergistic effects of local (oral) and systemic disease on human health, although there is a lack of methodological work to evaluate such joint effects with either disease specific (ie. oral health related QoL) or generic QoL instruments. The aim of this study is to evaluate methods that are optimal for measuring joint and synergistic effects on systemic conditions, oral disease and its treatment on quality of life. This study will measure oral health related QoL using the short form Oral Health Impact Profile (OHIP-14) and genetic QoL using the Medical Outcomes Study short-form health survey (SF-36). These questionnaires will be completed by 130 (terminal dentition) patients who have advanced dental disease and who have expressed an intent for ultimate removal of those teeth and placement with complete dentures. QoL measures will be administered at baseline, 4 weeks, 26 weeks and 52 weeks, and concurrent treatments and clinical status will be abstracted from treatment records. The data will be analyzed for psychometric independence of oral and generic QoL. Specific aims will be explored initially through cross- sectional analyses, where QoL measures will be the dependent variables and oral status (aim 1) or dental treatments (aim 2) will be the dependent variables. our study hypotheses will then be analyzed using longitudinal data analyzed using repeated measures of variance.