COMPREHENSIVE CANCER CENTER CORE SUPPORT GRANT

在过去的五年中，杜克综合癌症中心 继续履行其使命，作为一个“矩阵+”组织成熟起来。 五名年轻的调查员已被直接招聘到该科 细胞生长、调控与肿瘤发生。总体而言，招聘贯穿始终 杜克大学医学中心促进了癌症的生长 中心将包括255名成员，他们参与了12个项目。巨蟹座 中心的节目已重新组织，以更准确地反映 成员之间的互动，以及S更有效地促成 他们的合作。在结构性项目中建立了新的项目 生物学、宿主抗性和白细胞生物学，多学科临床 试验和癌症预防、检测和控制研究。共享 现在的资源包括23个设施，促进实验室和 临床癌症研究。在蛋白质领域建立了新的设施 结晶、二维凝胶分析、免疫细胞化学和体细胞 杂交。多肽资源得到了极大的加强 测序、分子图形、核磁共振、共聚焦 显微镜、住院临床研究、骨髓移植和 生物统计学。癌症中心隔离设施增加了一倍 尺码。新的建设已经启动，将提供40,000 NSF 为癌症中心研究人员提供更多基础和 搭桥科学。发展基金的使用使招聘成为可能 细胞生长、调控和肿瘤发生的部分，一个戏剧性的 拓展生物统计学，启动癌症预防、检测 和控制研究计划，心理社会调查中的招募， 加强共享资源、提供临时资金和 支持试点。由核心助学金，杜克大学 在过去的五年中，调查人员发表了超过4500篇论文 在细胞调控领域做出重大贡献的年份， DNA复制、结构生物学、病毒肿瘤学、白细胞生物学 神经肿瘤学、自体骨髓移植、妇科 肿瘤学，多学科治疗，临床应用 造血生长因子与癌症筛查。请求支持 针对高级领导、计划领导、管理、共享资源和 全面落实公爵战略部署的发展 综合癌症中心。

During the last five years the Duke Comprehensive Cancer Center has continued to fulfill its mission, maturing as a "matrix-plus" organization. Five young investigators have been recruited directly into the Section of Cell Growth, Regulation and Oncogenesis. Overall, recruitment throughout the Duke University Medical Center has facilitated growth of the Cancer Center to include 255 members who participate in 12 Programs. The Cancer Center's Programs have been reorganized to reflect more accurately interactions between members, as well s to facilitate more effectively their collaboration. New Programs have been established in Structural Biology, Host Resistance and Leukocyte Biology, Multidisciplinary Clinical Trials and Cancer Prevention, Detection and Control Research. Shared Resources now include 23 facilities that facilitate both laboratory and clinical cancer research. New facilities have been established in protein crystallization, 2-D gel analysis, immunocytochemistry and somatic cell hybridization. Resources have been substantially strengthened in peptide sequencing, molecular graphics, nuclear magnetic resonance, confocal microscopy, in-patient clinical research, bone marrow transplantation and biostatistics. The Cancer Center Isolation Facility has been doubled in size. New construction has been initiated that will provide 40,000 NSF of additional space for Cancer Center investigators in fundamental and bridging sciences. Use of development funds has permitted recruitment into the Section of Cell Growth, Regulation and Oncogenesis, a dramatic expansion of biostatistics, initiation of the Cancer Prevention, Detection and Control Research Program, recruitment in psychosocial investigation, strengthening of Shared Resources, provision of interim funding and the support of pilot projects. Facilitated by the Core Grant, Duke investigators have published greater than 4,500 papers during the last five years that have contributed substantially to the fields of cell regulation, DNA replication, structural biology, viral oncology, leukocyte biology, neurooncology, autologous bone marrow transplantation, gynecologic oncology, multidisciplinary treatment, clinical application of hematopoietic growth factors and cancer screening. Support is requested for Senior Leaders, Program Leaders, Administration, Shared Resources and Development to implement fully the strategic plan for the Duke Comprehensive Cancer Center.