CORE--MOUSE PATHOLOGY

拟议方案的所有三个项目都涉及研究 靶向基因产生的功能丧失突变的后果 在小鼠体内编码肿瘤抑制因子。这些研究需要专家和 大量样本（胚胎， 组织和肿瘤），研究表型表现影响 正常鼠发育和/或有助于肿瘤发生。的 诊断程序，这是核心的程序的发展 包括宏观解剖学检查、微观组织学检查、原位 杂交和免疫组织化学。 该核心设施的目的是提供小鼠病理学服务， 经验丰富的病理学家，结合他独特的背景知识， 人类临床病理学和小鼠发育和病理学， 包括肿瘤发生。核心区的质量控制将通过以下方式得到保证： 优化、规范和简化有关程序， [快速有效地提供口译。积极互动， 该计划的参与者预计，并应加强 开发涉及小鼠模型的项目。

All three projects of the proposed program involve the study of the consequences of loss-of-function mutations generated by targeting of genes encoding tumor suppressors in mice. These studies require expert and efficient pathological analyses of large number of specimens (embryos, tissues and tumors), to investigate phenotypic manifestations affect normal murine development and/or contributing to tumorigenesis. The diagnostic procedures that are central to the development of the program include macroscopic anatomic examination, microscopic histology, in situ hybridization and immunohistochemistry. The aim of this Core facility is to provide murine pathology serve by an experienced pathologist combining uniquely in his background expertise in both human clinical pathology and mouse development and pathology, including oncogenesis. Quality control in the Core will be secured by optimizing, standardizing nd streamlining the procedures involved, to [provide interpretations rapidly and efficiently. Active interactions with the program participants are anticipated and should enhanced the development of the projects involving mouse models.