CARCINOGENESIS AND NOVEL THERAPEUTICS IN ORAL CANCER

在芝加哥地区，口腔癌的研究有很长的历史。在……里面 这份申请书，芝加哥大学和西北大学 正在联合他们在实验室和临床科学方面的努力，以促进 实验室科学家和临床研究人员之间的互动， 产生新的治疗假说并进行转化性研究 口腔癌。我们将寻求优化现有的治疗方法，并 提高口腔癌患者康复水平。我们的长期合作 目标是确定早期诊断的新方法，以及更多 成功的治疗是基于对分子机制的理解 是这种疾病的潜在原因。我们将支持试点和快速 利用发展性生成新的临床实验室假说 研究经费由拨款提供，并由 参与机构并提供口头教育和培训 基础和临床研究人员的癌症研究。校长 调查人员有很长的合作历史，也 进行口腔致癌和癌症治疗的独立研究 和康复。此应用程序描述了四个项目 项目#1将研究口腔癌发生的潜在机制 可能会找出工具，以便将来早期发现。项目2将研究 细胞凋亡在口腔癌发生中的作用。项目3将研究分子 序贯放化疗的药代动力学研究 以提供更有效和毒性更低的治疗方法。项目4将测量 治疗后患者的器官功能与康复 意向放化疗。还包括三个试点项目，其中 将由两家公司提供的赠款和匹配资金提供资金 参与机构。这些活动将得到三个人的支持 核心。行政核心、生物统计、数据管理和 临床核心，组织采购和实验室核心。 核心A，行政核心将监测正在进行的项目，确保 成功和及时地执行科学任务，并与 内部和外部咨询委员会。核心B，生物统计学 数据管理和临床核心将提供数据方面的专业知识 收集和分析。核心C，实验室核心将负责 为了适当地收集、准备和分发人类 正在进行的项目所需的纸巾。

There is a long history of oral cancer research in the Chicago area. In this application, the University of Chicago and Northwestern University are combining their efforts in laboratory and clinical sciences to foster interactions between laboratory scientists and clinical investigators, to generate new treatment hypothesis and conduct translational research in oral cancer. We will seek to optimize currently available therapy and improve the rehabilitation of the oral cancer patient. Our long-term goals are to identify new approaches to early diagnosis and more successful therapy based on an understanding of the molecular mechanisms underlying this disease. We will support pilot projects and the rapid generation of new clinical laboratory hypotheses utilizing developmental research funds provided by the grant and supplemented by the participating institutions and provide education and training in oral cancer research for basic and clinical investigators. The principal investigators have a long history of collaboration and have also conducted independent studies of oral carcinogenesis and cancer therapy and rehabilitation. Four projects are described in this application Project #1 will examine mechanisms underlying oral carcinogenesis that may identify tools for future early detection. Project #2 will study the role of apoptosis in oral carcinogenesis. Project #3 will study molecular pharmacokinetics of chemotherapy with concomitant radiotherapy in order to deliver more effective and less toxic therapy. Project #4 will measure organ function and rehabilitation in patients treated with curative intent chemoradiotherapy. Three pilot projects are also included which will be funded by the grant and matching funds made available by the two participating institutions. These activities will be supported by three cores. The administrative core, the biostatistical, data management and clinical core, and the tissue procurement and laboratory core. Core A, the administrative core will monitor ongoing projects, assure successful and timely performance of scientific tasks and interact with the internal and external advisory boards. Core B, the biostatistical data management and clinical core will provide expertise in data collection and analysis. Core C, the laboratory core will be responsible for the appropriate collection, preparation and distribution of human tissues required for ongoing projects.