SCOR IN SUDDEN CARDIAC DEATH

约翰霍普金斯关于建立突发事件专门研究中心的建议 心源性死亡（SCD）旨在提高我们对SCD的理解， 最先进的分子方法来解决这个问题。 我们开始 前提是，如果我们能详细了解心脏兴奋性 在细胞和分子水平上起作用，这些知识就可以 有益地应用于预防SCD和合理的 识别和治疗有SCD风险的患者。 虽然我们的 提案广泛影响SCD，具体的临床问题， 我们试图阐明心脏病患者SCD的发病机制， 失败 我们的提案包括五个项目和一个核心，包括 来自两个临床和两个基础科学部门的研究人员。 项目1由Eduardo Marban博士指导，探索钠的功能 和钙在分子水平上。 项目2，由大卫博士指导 Yue博士试图确定抗肿瘤药物如何以及在何处阻断肿瘤细胞， 钠通道的孔隙。 威廉·阿格纽博士研究了 IP3受体的特性，它调节钙的释放， 细胞内储存。 除了探索激发的基本机制外，SCOR还将 探讨遗传学方法的可行性和可行性， 诊断和治疗容易发生SCD的患者。 最后两个项目 验证钾通道基因的特异性改变 心力衰竭中的表达通过产生异常而易患SCD 复极化的过程 由亚瑟费尔德曼和大卫博士指导的项目 Kass，研究了细胞中离子通道基因表达的变化， 心力衰竭和SCD动物模型。 临床评价，如 变化是项目8的主题，其中戈登·托马塞利博士和 同事们开发并测试了量化异常的新方法 复极和离子通道基因表达的变化 心衰

The Johns Hopkins proposal for a Specialized Center of Research in Sudden Cardiac Death (SCD) seeks to improve our understanding of SCD by bringing state-of-the-art molecular approaches to bear on the problem. We start with the premise that, if we can learn in detail how cardiac excitability works at the cellular and molecular levels, this knowledge can then be profitably applied to the prevention of SCD and to the rational identification and treatment of patients at risk for SCD. Although our proposal impacts broadly upon SCD, the specific clinical problem which we seek to elucidate is the pathogenesis of SCD in patients with heart failure. Our proposal consists of five projects and one core, including investigators from two clinical and two basic science departments. Project 1, directed by Dr. Eduardo Marban, probes the function of sodium and calcium at the molecular level. Project 2, directed by Dr. David Yue, seeks to determine how and where antiarrhythmic agents block the pores of sodium channels. Dr. William Agnew investigates the molecular properties of IP3 receptors, which regulate calcium release from intracellular stores. In addition to probing the basic mechanisms of excitation, the SCOR will explore the feasibility and advisability of genetic approaches to the diagnosis and treatment of patients prone to SCD. The final two projects test the hypothesis that specific alterations in potassium channel gene expression in heart failure predispose to SCD by producing abnormalities of repolarization. The project directed by Drs. Arthur Feldman and David Kass, investigates the changes in ion channel gene expression in an animal model of heart failure and SCD. The clinical evaluation of such changes is the subject of Project 8, in which Dr. Gordon Tomaselli and coworkers develop and test new approaches for quantifying abnormalities of repolarization and of ion channel gene expression in patients with heart failure.