47--TESLA MRI/MRS CONSOLE UPGRADE

需要对30厘米、4.7-T MRI/MRS动物进行控制台升级 研究体系。在它安装后的十年里，只有一个 系统组件已升级(梯度已在秋季升级 (1992年)。过时的小型计算机(24位、非Unix、非C或FORTRAN 可编程)、射频电子学和脉冲编程器 大大限制了它的实验能力，并使其变得非常复杂 新实验的开发/实施和在线实验 分析数据或传输用于离线分析的数据。因此， 设备的当前状态限制了以下两方面的进度 当前项目和未来项目的发展。有必要 今年夏天，升级当前的游戏机变得至关重要，因为它 可靠性突然降级到不可接受的水平(它从 在过去10年中，平均每月停机1天 从6月份开始，每月平均10天)。这一点进一步 降低了依赖此系统的调查人员的工作效率 进行他们由NIH资助的研究，并劝阻其他人 开始新的项目。请求的升级将使其成为 可靠、功能齐全的最先进系统。 一个由五个主要用户组成的小组将需要至少90%的 升级后的系统的总使用率。他们将开展的项目 包括以下内容：确定细胞机制调节 糖尿病视网膜病变致盲并发症 早产儿；阐明儿童癫痫发病的病理生理学； 评估预测肿瘤治疗反应的新方法；监测 体内对可卡因反应的脑神经化学；和设计 优化的数据收集和重建策略 在临床磁共振血管成像中的应用。所有这些都是 动物研究与正在进行的临床研究直接相关 使用免费方法进行人类和/或平行的基础研究。许多 在这个动物研究系统上开发的技术将是 直接转化为临床研究。其中一些项目只能 在升级到位的情况下启动，其余项目将 从拟议的升级中受益匪浅。

A console upgrade is requested for a 30-cm, 4.7-T MRI/MRS animal research system. Over the ten years since it was installed, only one system component has been upgraded (the gradients were upgraded in fall 1992). The obsolete minicomputer (24-bit, non-UNIX, non-C or -FORTRAN programmable), radiofrequency electronics, and pulse programmer significantly limit its experimental capability and greatly complicate both the development/implementation of new experiments and the on-line analysis of data or transfer of data for off-line analysis. Thus, the current state of the equipment limits both the rate of progress on current projects and the development of future projects. The need to upgrade out current console became critical this past summer when its reliability abruptly degraded to an unacceptable level (it went from an average of 1 day of down time a month over the previous 10 year period to an average of 10 days a month starting in June). This has further decreased the productivity of investigators who depend on this system to conduct their NIH-funded research and discouraged others from beginning new projects. The requested upgrade will make this a reliable, fully functional state-of-the art system. A group of five major users will require at least 90 percent of the total usage of the upgraded system. The projects they will conduct include the following: ascertain the cellular mechanisms regulating the blinding complications associated with diabetic retinopathy of prematurity; elucidate the pathophysiology of pediatric epileptogenesis; evaluate new approaches to predict tumor therapeutic response; monitor cerebral neurochemistry in response to cocaine in vivo; and design optimized data collection and reconstruction strategies for ultimate application to clinical magnetic resonance angiography. All of these animal studies are directly related to ongoing clinical studies in humans and/or parallel basic studies using complimentary methods. Many of the techniques developed on this animal research system will be translated directly to clinical studies. Some of the projects can only be initiated with the upgrade in place, and the remaining projects will benefit enormously form the proposed upgrade.