HIGH RESOLUTION MASS SPECTROMETER

该提案的目的是取代17岁的Kratos MS5O 普渡大学扇形磁高分辨质谱计 用最先进的磁扇形高分辨率质谱仪 Kratos MS 50是普渡大学唯一的高分辨率质谱仪， 它的年龄以及对它的沉重要求导致它失败 因此，这会危及一个大规模的研究进展。 NIH资助的研究人员遍布校园。 除了更像 比MS50更可靠，一种新的磁扇区高分辨率质量 质谱仪将提供与MS 50相比的优势， 范围，电喷雾电离能力，它将提供一个合适的 新的仪器将位于该部门 药物化学和分子药理学，并将纳入 现在的校园质谱中心（CWMSC）。因此，在本发明中， 它将服务于校园内70多个不同的研究小组， 20个学术部门由目前资助的质谱仪 申请将由现行政策管理，适用于 Kratos MS50仪器 质谱监督 委员会将与适当的销售代表会面， 候选仪器的规格和性能，并将 最后的选择。 此外，该委员会将选择测试 样品，检查测试样品的结果，并最终协调 仪器的安装。 校园弥撒的负责人 质谱中心、部门质谱操作员和 电子技术员将与安装工程师一起工作， 尽可能熟练地维护和操作新的 仪器 该工具将得到联合国的财政支持。 药物化学与分子药理学系 化学系，普渡癌症中心，并由用户收费 基于执行服务所需的时间。收费率将 由系主任与学院协商确定 负责质谱分析的部门代表 实验室和CWMSC主任。

The purpose of this proposal is to replace the 17 year-old Kratos MS5O magnetic sector high resolution mass spcctrometer at Purdue University with a state of the art magnetic sector high resolution mass spectrometer. The Kratos MS50 is the only high resolution mass spectrometer at Purdue, and its age as well as the heavy demands placed on it cause it to fail on a regular basis, thus jeopardizing the research progress of a large number of NIH-funded investigators across campus. Besides being more reliable than the MS50, a new magnetic sector high resolution mass spectrometer will offer the advantages vs. the MS50 of extended mass range, eletrospray ionization capabilities, and it will provide a suitable platform for HPLC-MS. The new instrument will be located in the Department of Medicinal Chemistry and Molecular Pharmacology and will be incorporated into the present Campus-wide Mass Spectrometry Center (CWMSC). As such, it will serve over 70 different research groups across campus located in 20 academic departments. The mass spectrometer funded by the present application will be administered by an existing policy which applies to the current Kratos MS50 instrument. The Mass Spectrometry Oversight Committee will meet with the appropriate sales representatives, review the specifications and performance of the candidate instruments and will make the final selection. In addition, this committee will select test samples, examine the test sample results and ultimately coordinate the installation of the instrument. The Director of the Campus-wide Mass Spectrometry Center, the Departmental Mass Spectrometry Operator and the Electronics Technician will work with the Installation Engineer to become as proficient as possible in the maintenance and operation of the new instrument. The instrument will be supported financially by the Department of Medicinal Chemistry and Molecular Pharmacology, the Department of Chemistry, the Purdue Cancer Center, and by charges to users based on the time required to perform the service. The charge rate will be set by the Department Head in consultation with the Faculty Representative of the Department responsible for the Mass Spectrometry Laboratory and the Director of the CWMSC.