MERCURY 400 MHZ BROADBAND NMR SYSTEM

药学院在研究领域保持着强大的存在 毒理学、酶机制、分子生物学、膜活性 多肽，酶抑制剂的合理设计，以及新的努力 专注于组合化学和催化抗体。全 这些研究领域的共同之处在于产生和研究的小 因此它们迫切需要获得常规的核磁共振 分光计。目前，所有常规的核磁共振波谱都在进行 在已有八年历史的通用电气QE-300型光谱仪上 300兆赫。这台光谱仪的长期使用期限是 问题越来越多。通用电气出售其高分辨率 核磁共振波谱仪部门于1992年移交给布鲁克。而布鲁克则维持着 在1999年QE-300之前支持该文书的合同义务 基本上已经成了“孤儿”。没有新的硬件或 为任何以前的GE仪器进行软件开发。最关键的 是部件和电路板仅限于手头的部件还是什么 可以从拆卸的仪器中回收。因此，虽然需要 快速获得现代常规核磁共振波谱仪的机会增加了 学校，我们面临着一场危机，我们所依赖的光谱仪 这些需求不再得到制造商的充分支持，是 越来越容易受到灾难性故障的影响，并已成为 已经过时了。因此，我们请求资金购买一辆瓦里安 水星400兆赫光谱仪取代QE-300。

The School of Pharmacy maintains a strong presence in the research areas of toxicology, enzyme mechanisms, molecular biology, membrane-active peptides, rational design of enzyme inhibitors, and new efforts are being focused in combinatorial chemistry and catalytic antibodies. All of these research areas have in common the generation and study of small molecules and thus they have a critical need for access to a routine NMR spectrometer. At present all routine NMR spectroscopy Is being conduced on an eight-year old General Electric QE-300 spectrometer operating at 300 MHz. The long term availability of this spectrometer is increasingly problematic. General Electric sold off its high resolution NMR spectrometer division to Bruker in 1992. While Bruker maintains a contractual obligation to support the instrument until 1999 the QE-300 has been essentially "orphaned". There has been no new hardware or software development for any of the former GE instruments. Most crucial is that parts and circuit boards are limited to those on hand or what can be salvaged from dismantled instruments. Thus while the need for rapid access to a modern routine NMR spectrometer increases in the School, we face a crisis that the spectrometer we rely on to provide for those needs is no longer adequately supported by the manufacturer, is increasingly susceptible to catastrophic failure, and has become obsolete. We therefore request funds for the purchase of a Varian Mercury 400 MHz spectrometer to replace the QE-300.