BIOBEHAVIORAL STUDIES OF CARDIOVASCULAR DISEASE

项目1的主要目的是检验个人 行为诱发的心血管反应性的差异是 与动脉粥样硬化和左室指标呈正相关 既往未经治疗的高血压患者的心室扩大。 之间 该项目的具体目标是确定：（a）是否 血流动力学调节的幅度和模式的可变性 由行为刺激（压力）引起的与 颈动脉粥样硬化和/或左室舒张功能增加的证据 高血压个体中的心室质量;（B）是否这样 非裔美国人和非裔美国人之间的关系在性质上各不相同， 高加索高血压;以及（c）是否存在个体差异， 心血管反应性介导的心理社会因素关系 (e.g.,愤怒/敌意;社会支持）与动脉粥样硬化或左 高加索人和非裔美国人的心室质量。 我们 拟招募400名临界和轻度高血压男性，定义如下： 收缩压在140到180毫米汞柱之间。收集数据 包括：（a）对一组 行为（认知、心理和人际）挑战;（B） 颈动脉疾病的超声测量;（c）超声心动图 左心室结构和功能的测量，以及 血管顺应性的非侵入性评估;（d）心理社会因素 既往患有高血压或冠心病;以及（3） 心血管疾病的几种已知或推定的危险因素（例如， 空腹胰岛素、血脂浓度、动态血压， 第一次系统研究心血管疾病 对动脉粥样硬化和左心室质量的反应性， 既往未接受过治疗的原发性高血压样本。 其次，这项研究将提供重要的新信息， 心室形态，血管顺应性， 颅外颈动脉疾病和对压力的血流动力学反应， 以及这些参数与社会心理因素的关系 对心血管疾病有潜在意义。

The principal aim of Project 1 is to test the hypothesis that individual differences in behaviorally evoked cardiovascular reactivity are associated positively with atherosclerosis and indices of left ventricular enlargement among previously untreated hypertensives. Among the specific objectives of this project are to determine: (a) whether variability in the magnitude and patterning of hemodynamic adjustments induced by behavioral stimuli (stress) are associated with extent of carotid artery atherosclerosis and/or evidence of increased left ventricular mass among hypertensive individuals; (b) whether such relationships vary in nature of magnitude between African-American and Caucasian hypertensive; and (c) whether individual differences in cardiovascular reactivity mediated relationships of psychosocial factors (e.g., anger/hostility; social support) with atherosclerosis or left ventricular mass among Caucasian and African-American individuals. We propose to recruit 400 borderline and mild hypertensive men, defined by systolic blood pressure between 140 and 180 mm Hg. Data to be collected on each patient include: (a) cardiovascular responses to a battery of behavioral (cognitive, psychomotor and interpersonal) challenges; (b) ultrasound measurements of carotid artery disease; (c) echocardiographic measurements of left ventricular structure and function, as well as noninvasive evaluations of vascular compliance; (d) psychosocial factors previously implicated in hypertension or coronary disease; and (3) several known or putative risk factors for cardiovascular disease (e.g., fasting insulin, serum lipid concentrations, ambulatory blood pressure, the first systematic study of the relationship of cardiovascular reactivity to both atherosclerosis and left ventricular mass in a biracial hypertensive sample uncomplicated by prior treatment. Secondarily, this study will provide important new information regarding racial differences in ventricular morphology, vascular compliance, extracranial carotid artery disease and hemodynamic reactions to stress, as well as the relationship of these parameters to psychosocial factors of potential significance for cardiovascular disease.