CoEN5028 Can a dysfunction of the basal ganglia and related low level nociceptive network underlie some central neuropathic pain symptoms in..

疼痛是帕金森病（PD）中一种非常常见和棘手的症状，但对其了解甚少。PD中的中枢神经性疼痛通常被患者描述为其他原因不明的疼痛感觉，没有明显的起源，主要发生在受影响的一侧。中枢神经性疼痛被认为起源于中枢神经系统的功能障碍，这表明允许我们感知和处理疼痛的大脑回路在帕金森病中可能功能障碍。虽然在一些涉及疼痛的皮质结构中已经报道了异常的伤害性处理，但迄今为止还没有明确的病理生理机制来解释这些特定的症状。基于我们最近发现的一种新的伤害性网络，我们建议测试一个新的假设连接中枢神经性疼痛症状的异常活动之间的基底神经节，一组已知的结构是功能障碍的帕金森氏病，和初级伤害性结构脑干，臂旁核。我们还建议测试这个网络是否可以作为丘脑底核脑深部刺激对中枢疼痛症状的有益影响的基础。

Pain is a very common and troublesome, but poorly understood symptom in Parkinson's disease (PD). Central neuropathic pain in PD is often described by patients as otherwise unexplained painful sensations with no apparent origin, predominantly on the more affected side. Central neuropathic pain is thought to originate from a dysfunction of the central nervous system suggesting that the brain circuits that allow us to perceive and process pain could be dysfunctional in Parkinson's disease. While abnormal nociceptive processing has been reported in some cortical structures involved in pain, there is to date no clear pathophysiological mechanism to explain these specific symptoms. Based on our recent discovery of a novel nociceptive network, we propose to test a new hypothesis linking central neuropathic pain symptoms to abnormal activity of this nociceptive network between the basal ganglia, a group of structures known to be dysfunctional in Parkinson's disease, and a primary nociceptive structure within the brainstem, the parabrachial nucleus. We also propose to test whether this network could underlie the beneficial effect of deep brain stimulation of the subthalamic nucleus on central pain symptoms.