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MATURATIONAL ROLES OF GONADOTROPIN RELEASING HORMONE (GNRH) PULSE FREQUENCY

MATURATIONAL ROLES OF GONADOTROPIN RELEASING HORMONE (GNRH) PULSE FREQUENCY
促性腺激素释放激素 (GNRH) 脉冲频率的成熟作用
批准号：
6113339
负责人：
CAROL M FOSTER
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113339
关键词：
clinical research endogenous opioid estradiol gonadotropin releasing factor hormone regulation /control mechanism human subject menstrual cycle neuroendocrine system reproductive development testosterone

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中文摘要
翻译
本研究旨在探讨人类性成熟过程中中枢神经系统对促性腺激素分泌的调控变化。提出的研究是基于这样的假设：促性腺激素释放激素（GnRH）脉冲频率在人类性成熟和整个月经周期中起调节作用。具体来说，我们建议评估主要的性类固醇，睾酮(T)和雌二醇（e[2]）对GnRH分泌的影响。我们还建议研究内源性阿片通路是否以及何时参与人类性成熟过程中GnRH分泌的调节。
英文摘要
The purpose of this research is to investigate the changes in the central nervous system control of gonadotropin secretion during sexual maturation of human beings. The proposed studies are based on the hypothesis that gonadotropin-releasing hormone (GnRH) pulse frequency plays a regulatory role in human sexual maturation and throughout the menstrual cycle. Specifically, we have proposed to evaluate the effects of the principal sex steroids, testosterone (T) and estradiol (E[2]), on GnRH secretion. We have also proposed to examine whether, and if so when, endogenous opioid pathways become involved in the regulation of GnRH secretion during human sexual maturation.
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FSH AND THE ONSET OF PUBERTY--GANIRELIX
  • 批准号：
    7718518
  • 项目类别：
  • 资助金额：
    $1.6万
  • 财政年份：
    2008
  • 负责人：
    CAROL M FOSTER
  • 依托单位：
    UNIVERSITY OF UTAH
FSH AND THE ONSET OF PUBERTY--GANIRELIX
  • 批准号：
    7604976
  • 项目类别：
  • 资助金额：
    $10.18万
  • 财政年份：
    2007
  • 负责人：
    CAROL M FOSTER
  • 依托单位：
    UNIVERSITY OF UTAH
Hypoglycemia and Quality of Life: Comparison of Insulin Therapies in Pre-School
Mechanisms of Constitutional Growth Delay
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