BIOLOGICAL AND PHARMACOLOGICAL ASSESSMENT OF GPIIB/IIIA RECEPTOR

糖蛋白（Gp）IIb/IIIa是膜结合粘附分子的整合素超家族的成员。 血小板膜糖蛋白具有高度多态性，可被识别为同种或自身抗原。各种血小板表面糖蛋白上的表位的不相容性是同种免疫性血小板减少症的原因。 免疫介导的血小板破坏综合征中最常见的同种异体抗原是PLA（或Zw）。 一项病例对照研究表明，PlA 2等位基因与不稳定冠状动脉综合征之间存在强相关性，尤其是在60岁以下的个体中。 然而，随后的研究并没有证实这一观察结果。本研究旨在描述健康北美受试者中GP IIb/IIa基因型及其与纤维蛋白原结合的相关性。将对100名健康志愿者进行糖蛋白（GP）IIb/IIa的基因型分析，并在30名个体的亚组（15对平衡对）中评估GP IIb/IIIa基因型与纤维蛋白原结合程度之间的相关性。

The glycoprotein (Gp) IIb/IIIa is a member of the integrin superfamily of membrane-bound adhesion molecules. Platelet membrane glycoproteins are highly polymorphic and can be recognized as allo-or self-antigens. Incompatibility of epitopes on the various pletelet surface glycoproteins is responsible for the alloimmune thrombocytopenias. The alloantigen most frequently implicated in syndromes of immune mediaated platelet destruction is PLA (or Zw). A case-control study has shown a strong association between the PlA2 allele and unstable coronary syndromes, especially in individuals less than 60 years of age. However, subsequent studies did not confirm this observation. The present study wants to characterize the Gp IIb/IIa genotype and its correlation with fibrinogen binding in healthy North-American subjects. Genotypic analyses of the glycoprotein (Gp) IIb/IIa will be performed on 100 healthy volunteers and the correltation between the GP IIb/IIIa genotype and the extent of fibrinogen binding will be assessed in a subgroup of 30 individuals (15 balanced pairs).