LINKAGE ANALYSIS OF THE LONG QT SYNDROME

本研究的目的是确定与上述基因座无关的长QT综合征家族，并确定与LQT1、LQT2或LQT3基因座相关的家族突变。我们打算获得并发心电图（ECG）和血液样本进行白细胞DNA分析，以检查分别位于第11、7、3和4号染色体上的LQT1、2、3和4位点与心电图上的长QT间期之间的联系。鉴定与这些基因座无关的家庭对于鉴定可能导致这种危及生命的疾病的其他基因非常重要。此外，识别与先前描述的基因之一相关的家庭突变将进一步加深我们对疾病过程的理解。

The aim of this research is to identify long QT syndrome families not linked to one of the previously described loci and to identify mutations in families linked to the LQT1, LQT2 or LQT3 loci. We intend to obtain concurrent electrocardiograms (ECG) and blood samples for leukocyte DNA analysis to examine for linkage between the LQT1, 2, 3 and 4loci on chromosomes 11, 7, 3 and 4 respectively and a long QT interval on the ECG. Identification of families not linked to one of these loci will be important in identifying other genes that can cause this life-threatening disorder. Also, identifying mutations in families linked to one of the previously-described genes will further our understanding of the disease process.