STUDIES ON THE GENETICS OF NONINSULIN DEPENDENT DIABETES MELLITUS (NIDDM)

非胰岛素依赖型糖尿病(NIDDM)遗传学研究(GENNID)的目标是收集一种可再生的遗传物质来源，用于与类似的NIDDM研究相关联，基于从受影响的同胞对确定的家系。在当前期间(1998年12月1日至1999年1月12日)，我们将招募30个扩展家系，包括至少两个受影响的兄弟姐妹，一个未受影响的配偶对照，以及未受影响的兄弟姐妹和父母(如果有)。临床和家族病史将被记录在永久数据库中，以及相关的实验室研究，包括胰岛B细胞功能、胰岛素作用、肾功能和脂代谢的测量。将建立永久细胞系，以获得无限来源的DNA。此外，将招募30个家庭，只研究受影响的同胞对。这一资源将为未来的研究人员提供必要的材料，以寻求糖尿病表型的基因决定因素。

The goal of the Genetics of Non-Insulin Dependent Diabetes Mellitus (NIDDM) (GENNID) study is to collect a renewable source of genetic material for linkage an similar studies of NIDDM, bases upon pedigrees ascertained from an affected sibling pair. During the current period (12/1/98 - 12/1/99) wee will recruit 30 extended pedigrees, including at least two affected sibs, an unaffected spouse control, and unaffected sibs and parents when available. Clinical and family histories will be recorded in a permanent databae, along wit pertinent laboratory studies including measures of pancreatic islet b-cell function, insulin action, renal function, and lipid metabolism. Permnent cell lines will be established for an unlimited source of DNA. In addition, 30 families will be recruited with only affected sib pairs studied. This resource will provide the necessary materials for future investigators to pursue the genotypic determinants of diabetic phenotypes.