EFFECTS OF LIPID LOWERING ON CORONARY INTIMAL STRUCTURE AND ENDOTHELIAL FUNCTION

许多研究已经表明，对患有高血压和确诊的冠状动脉疾病（CAD）的患者进行治疗，尽管血管造影狭窄程度有少量改善，但导致随后的临床事件如心肌梗死（MI）和死亡显著减少。不仅是造成这种差异的机制尚不清楚，临床事件的替代品的缺乏使得降脂治疗的益处的研究变得困难。 我们将检查血管内超声的影响，并通过对乙酰胆碱和腺苷的反应评估冠状动脉循环中的心外膜血管内皮功能和阻力血管功能，受试者将是已知和记录的冠状动脉疾病和LDL胆固醇水平中度升高的患者。

A number of studies ahve shown that treatment of patients with hyprlipidemia and established coronary artery disease (CAD results in marked reduction of subsequent clinical events such as myocardial infarction (MI) and death, in spite of small amounts of improvement in angiographic degree of stenosis. Not only is the mechanism causing this discrepancy unclear, the lack of a surrogate for clinical events makes studies of the benefits of lipid lowering therapy difficult. We will examine the effect of intravascular ultrasound, and on epicardial vessel endothelial function and resistance vessel function in the coronary circulation assessed by the response to acetylcholine and adenosine, in subjects will be patients with known and documented coronary artery disease, and a moderately elevated LDL cholesterol level.