Consortium to Research Individual, Interpersonal, and Social influences in Pain (CRIISP)

(i)目标和目标西班牙持续时间长（慢性），会破坏生活、关系和家庭。尽管生物信号可以帮助理解疼痛发生的原因，但它们并不能完全解释人们的经历，也不能解释为什么疼痛会以这种方式发展。心理和社会因素，如思想和感觉、人际关系和生活方式，也会影响慢性疼痛。然而，我们还不知道这些心理和社会机制中哪一个是最重要的，或者它们是如何与生物信号结合起来影响慢性疼痛的。我们的目的是确定慢性疼痛的社会心理机制。我们的目标是创建一个更清晰的解释，社会心理因素（与生物学相互作用）如何以及以何种方式影响疼痛：是什么导致慢性疼痛开始、持续、好转或恶化。在此过程中，我们还将找到预防慢性疼痛发生的方法，并减少疼痛对人们生活的负面影响。（ii）需要收集的数据我们将关注人们如何思考和感受疼痛，其他人如何影响他们的疼痛，并考虑更广泛的社会和环境对疼痛的影响。这些社会心理机制将反过来在慢性疼痛的生理和生物医学方面的背景下进行描述。我们计划的工作在每个阶段都涉及到患有疼痛的人，以确保我们的工作以疼痛影响人们生活的方式为指导。我们将从探索现有证据开始，以确定最重要的是什么，包括哪些措施和方法最能反映生活经验。我们将询问患有疼痛的人，这些因素中哪一个最重要，并在现有的大型数据集中进行测试。我们将对最有希望的心理和社会因素进行新的研究。我们将探索人们的思维和行为方式是如何导致疼痛的，并观察人们是如何带着疼痛生活的。我们将研究人们适应疼痛的方式，并通过我们感兴趣的因素确定在慢性疼痛中所起的作用。（iii）联合体的好处联合体的方法使我们能够想得更大。它给了我们一个难得的机会来改变我们对疼痛的看法和研究方式。为了实现这些雄心勃勃的目标，我们需要汇集不同科学学科的专业知识，与疼痛患者一起，以一种以前不可能实现的方式。高级疼痛发现平台（APDP）不仅使我们能够做到这一点，而且还为我们提供了一个前所未有的前景，即在概念层面上始终如一地工作，生成数据和测试想法。它还允许跨联盟工作，刺激和评估新的想法，并为未来的疼痛研究和发现发现机会。（iv）网络的传承和/或可持续性我们的主要贡献将是确定对理解疼痛最重要的心理和社会因素。我们将开发研究疼痛的新方法，疼痛及其影响的新措施，最重要的是确定疼痛的关键社会心理机制，展示它们如何与生物学一起促进或限制疼痛。我们将提供关于这些社会心理机制的指导，并将这些资源置于APDP中，供更广泛的跨学科疼痛研究团体使用，包括那些希望将社会心理因素纳入医学流行病学，临床或人类基因分型研究的人。通过我们的工作，以及由此产生的伙伴关系，我们将为疼痛研究开辟新的、广阔的途径，开发出更好的方法，帮助人们在减轻疼痛的情况下生活得更好。

(i) Aims and objectivesPain that lasts a long time (is chronic) takes apart lives, relationships and families. Although biological signals can help understand why pain happens, they do not fully account for the experiences people have, or why pain develops the way it does. Psychological and social factors, such as thoughts and feelings, personal relationships, and lifestyle, can also affect chronic pain. However, we do not yet know which of these psychological and social mechanisms are most important, or how they combine with biological signals to affect chronic pain. Our aim is to determine the psychosocial mechanisms underpinning chronic pain. Our objective is to create a clearer account of how, and in what way, psychosocial factors (interacting with biology) affect pain: what makes chronic pain start, keep going, get better or get worse. In doing so, we will also identify ways to prevent chronic pain from happening, and reduce the negative effects that pain can have on people's lives. (ii) Data to be collectedWe will focus on how people think and feel about pain, how others affect their pain, and consider the wider social and environmental influences on pain. These psychosocial mechanisms will in turn be described in the context of physiological and biomedical dimensions of chronic pain. Our planned work involves people with pain at each stage to ensure our work is guided by the way pain affects people's lives. We will start by exploring the existing evidence, to identify what matters most, including what measures and methods best reflect lived experience. We will ask people with pain which of these factors matter most, and test them in existing large datasets. We will run new studies on the psychological and social factors that hold greatest promise. We will explore how the way people think and behave contributes to pain, and observe how people live their lives with pain. We will study the ways people adapt to live well with pain, and identify the part played in chronic pain by the factors we are interested in. (iii) Benefits of the consortiumA consortium approach allows us to think big. It gives us a rare opportunity to change how we think about pain and how we research it. To achieve these ambitious goals, we need to bring together expertise from different scientific disciplines, alongside people with pain, and in a way that has not previously been possible. The Advanced Pain Discovery Platform (APDP) not only allows us to do this, but also offers us an unprecedented prospect of working consistently at a conceptual level, to generate data and test ideas. It also allows for cross-consortium working, to stimulate and evaluate new ideas and spot opportunities for future pain research and discovery.(iv) Legacy and/or sustainability of the network Our primary contribution will be to identify the psychological and social factors that are most important for understanding pain. We will develop new ways to study pain, new measures of pain and its impacts, and most importantly identify key psychosocial mechanisms of pain, showing how they work alongside biology to promote or limit pain. We will provide guidance about these psychosocial mechanisms, and place this resource within the APDP, for use by the wider interdisciplinary pain research community, including those who wish to incorporate psychosocial factors in medical-epidemiological, clinical, or human genotyping studies. Through our work, and the partnerships that generated it, we will open new, broad avenues of pain research that will develop better ways to help people to live well with less pain.