EFFECTS OF GROWTH FACTORS ON PROTEIN TURNOVER IN THE ELDERLY

本研究的主要假设是生长激素和性激素 替换可以防止或限制瘦身质量的下降。 随着年龄的增长。具体而言，本议定书将评估其影响 激素替代对全身蛋白质周转的影响，作为一项指标 骨骼肌蛋白质分解代谢率。 1997年完成的议定书是正在进行的更大规模研究的一部分 生长因子对能量消耗、身体成分和骨骼的影响 1993年开始对老年人的肌肉质量进行了调查。所有的病人都是为了 这项研究是通过贝维尤约翰霍普金斯医院招募的。 每名患者均为65岁及以上年龄组，身体健康， 久坐不动，但能走动。

The main hypothesis of the present study is that GH and sex steroid replacement can prevent or limit the decline in lean mass that occurs with aging. Specifically, the present protocol will assess the impact of hormone replacement on whole-body protein turnover, as an index of skeletal muscle protein catabolic rate. The protocol accomplished in 1997 is part of an ongoing larger study of growth factors on energy expenditure, body composition and skeletal muscle mass in older persons that started in 1993. All patients for the study have been recruited through the Bayview Johns Hopkins Hospital. Each patient belongs to the age group of 65 and over and is healthy, sedentary but ambulatory.