DIET, APOLIPOPROTEIN PHENOTYPES & CIRCULATING ESTROGENS IN BREAST CANCER

在绝经后妇女中进行的初步研究，这些妇女有雌激素受体阳性的乳腺癌病史和已知影响血清脂质水平的特定载脂蛋白E表型，以确定进行更大规模研究的可行性，研究饮食脂质和纤维摄入量之间的关系，载脂蛋白E表型和循环血清雌激素水平，在患有已知受雌激素影响的疾病（乳腺癌）的妇女中。门诊研究将在6名女性中进行。在2 - 4周内，受试者将被喂食高脂肪、低纤维饮食，在4-6周内，受试者将被喂食低脂肪、高纤维饮食，目的是确定需要多少周才能看到循环雌激素水平的变化。该研究将使用GCRC 8个月。

Pilot study done in post-menopausal women with a history of estrogen-receptor positive breast cancer and specific apolipoprotein E phenotypes known to affect serum lipid levels, to determine the feasibility of doing a larger study looking at the relationship between diet lipid and fiber intake, apolipoprotein E phenotype and circulating serum estrogen levels, in women with a disease (breast cancer) known to be affected by estrogen. The outpatient study will be done in 6 women. For 2 to 4 weeks, the subjects will be fed a high fat, low fiber diet, and for 4-6 weeks the subjects will be fed a low fat, high fiber diet, with the intent of determining how many weeks are required before changes in circulating estrogen levels are seen. The study will utilize the GCRC for 8 months.