INTERACTION BETWEEN GENE EXPRESSION & DNA DAMAGE DUE TO IONIZING RADIATION
INTERACTION BETWEEN GENE EXPRESSION & DNA DAMAGE DUE TO IONIZING RADIATION
批准号:
6118590
负责人:
JOSEPH L ROTI ROTI
金额:
$0.04万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-08-01 至 1999-07-31
中文摘要
本研究的一个主要目标是综合模型系统的
电离辐射对DNA的损伤及对转录的影响
在体外和体内。 我们最近的工作重点是
设计和合成光可裂解的DNA构建模块,
产生“笼状”DNA单链和双链断裂。
需要常规高分辨率质谱来表征
合成这些结构单元的中间体
英文摘要
A major goal of this research is to synthesize model systems of
ionizing radiation damaged DNA and study the effect on transcription
in vitro and in vivo. Our recent work has been specifically focused
on the design and synthesis of photocleavable DNA building blocks for
the production of "caged" DNA single and double strand breaks.
Routine high resolution mass spectrometry is required to characterize
intermediates in the synthesis of these building blocks
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会议论文
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Core A: Administration and Laboratory Support Core
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依托单位:
ROLE OF THE NUCLEAR MATRIX IN DOUBLE STRAND BREAK REPAIR
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批准号:6103414
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资助金额:$15.32万
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财政年份:1999
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负责人:JOSEPH L ROTI ROTI
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依托单位:
ROLE OF THE NUCLEAR MATRIX IN DOUBLE STRAND BREAK REPAIR
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资助金额:$15.22万
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财政年份:1998
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负责人:JOSEPH L ROTI ROTI
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依托单位:
CELLULAR STRESS RESPONSE AND RADIOSENSITIVITY
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资助金额:$91.32万
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财政年份:1997
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CELLULAR STRESS RESPONSE AND RADIOSENSITIVITY
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财政年份:1997
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依托单位:
ROLE OF THE NUCLEAR MATRIX IN DOUBLE STRAND BREAK REPAIR
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项目类别:
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资助金额:$15.51万
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财政年份:1997
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负责人:JOSEPH L ROTI ROTI
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依托单位:
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财政年份:1997
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依托单位:
CELLULAR STRESS RESPONSE AND RADIOSENSITIVITY
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资助金额:$24.23万
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财政年份:1997
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负责人:JOSEPH L ROTI ROTI
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依托单位:
CELLULAR STRESS RESPONSE AND RADIOSENSITIVITY
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资助金额:$59.73万
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财政年份:1990
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负责人:JOSEPH L ROTI ROTI
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依托单位:
NUCLEAR DETERMINANTS OF THERAPEUTIC RESPONSE
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批准号:3094448
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项目类别:
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资助金额:$60.0万
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财政年份:1990
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负责人:JOSEPH L ROTI ROTI
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依托单位:
NUCLEAR DETERMINANTS OF THERAPEUTIC RESPONSE
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批准号:2094127
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项目类别:
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资助金额:$67.03万
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财政年份:1990
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负责人:JOSEPH L ROTI ROTI
-
依托单位:
海外基金