Pioneering Renovite nanoclay gels in cell therapy

合成纳米粘土可以形成充当组织模板的水凝胶，并且可以用于封装、递送和关键地将各种分子保留在所需部位以影响组织再生。至关重要的是，Renovos一直在开创性地使用这种新型材料Renovite作为局部蛋白质输送的注射凝胶用于医疗应用。我们现在已经建立了Renovite纳米粘土凝胶的新合成能力，扩展了再生医学中这种工业可持续生物材料的开发途径。由于纳米粘土凝胶具有定位和保留分子的能力，这种类型的局部递送应用提供了更好的安全性，并允许降低许多生物制剂的有效剂量，否则这些生物制剂可能是有毒的。纳米粘土凝胶也是递送细胞的潜在优秀候选者，因为纳米粘土允许营养物质的扩散，并且其基本物理性质模拟细胞的天然环境。我将率先使用这种新型的合成凝胶生物材料用于细胞治疗，建立在Renovos内的再生蛋白质递送背景以及我在干细胞研究方面的专业知识和兴趣。从医疗和商业角度来看，最大的未满足需求是新型生物材料解决方案，其改善用于软骨再生的临床实践中使用的细胞（软骨细胞/自体软骨细胞植入或ACI）或用于软骨和骨中再生和免疫调节应用的骨髓抽吸物（BMA）的递送和定位。该奖学金将通过提供基于具有成本效益，破坏性和高度竞争力的纳米粘土生物材料的尖端解决方案来提供细胞治疗创新。

Synthetic nanoclays can form hydrogels that act as tissue templates and can be used to encapsulate, deliver and crucially, retain various molecules at a required site to influence tissue regeneration. Critically, Renovos has been pioneering the use of this novel material, Renovite, for medical applications as an injectable gel for localised protein delivery. We have now established a new synthesis capability for Renovite nanoclay gels, extending the avenues for development for this industrially sustainable biomaterial across regenerative medicine. Due to the ability of the nanoclay gels to localise and retain molecules, this type of local delivery application offers improved safety and allows for lowering of the effective dose of many biologics that can be otherwise toxic.Nanoclay gels are also potentially excellent candidates for delivering cells as the nanoclays allow diffusion of nutrients and their basic physical properties mimic the cell's native environment. I will pioneer the use of this novel, synthetic gel biomaterial for application in cell therapy, building on the regenerative protein delivery background within Renovos and my expertise and interests in stem cell research. The largest unmet need from a medical and commercial perspective is novel biomaterial solutions that improve delivery and localisation for cells used in clinical practice (chondrocytes / autologous chondrocyte implantation or ACI) for cartilage regeneration or bone marrow aspirates (BMAs) for regenerative and immune modulating applications in cartilage and bone. This fellowship will provide innovation in cell therapy by delivering cutting-edge solutions based on a cost-effective, disruptive and highly competitive nanoclay biomaterial.