SEQUENTIAL KIDNEY/PANCREATIC ISLET CELL TRANSPLANTATION

我们将进行总共20个连续的肾胰岛移植。 的 将胰岛通过门静脉经皮注射到肝脏中。 接受者将是具有稳定功能的肾脏的患者， 患有1型糖尿病。 我们的研究将有助于确定 候选人，免疫抑制剂，位点，和胰岛的可行性 移植 在移植前，C肽阴性将是 使用胰高血糖素激发进行验证。 1周、1个月、3个月、6个月时 月和1-5年每年评估胰岛素分泌 使用sustacal膳食挑战测试。

We will perform a total of 20 sequential kidney islet transplants. The islets will be injected percutaneously into the liver via the portal vein. The recipients will be patients who have a stable functioning kidney and have type 1 diabetes. Our research will help define the optimal candidates, immunosuppression, site, and feasibility of pancreatic islet transplantation. Prior to transplantation, C-peptide negativity will be verified using a glucagon challenge. At 1 week, 1 month, 3 months, 6 months, and yearly from 1-5 years, insulin secretion will be assessed using a sustacal meal challenge test.