AIDS RELATED NON HODGKINS LYMPHOMA, KAPOSIS SARCOMA & OTHER MALIGNANC

国家癌症研究所病毒流行病学分部正在启动一项新的队列和嵌套病例对照研究，研究对象为人类免疫缺陷病毒(HIV)相关免疫抑制人群中发生的癌症。将从艾滋病治疗和临床试验地点招募5000名受试者，并对癌症终点进行前瞻性跟踪。将收集癌症病例的基线数据和血样。预计将有150例非霍奇金淋巴瘤，类似数量的卡波西肉瘤，以及大约45例其他癌症，超过3年的随访期。这项研究的数据将被用来确定艾滋病毒相关恶性肿瘤的发病率和风险因素。艾滋病毒的治疗方法将作为潜在的风险因素进行专门调查。将对生物样本进行分析，以寻找与艾滋病毒相关的致癌因素和中间标志物。这项研究将产生与癌前血清和淋巴细胞相关的HIV相关肿瘤的集合，比目前美国任何自然历史队列都要大。这些材料将提高我们描述艾滋病毒相关癌变的能力，并解决有关肿瘤的基本问题。

The Viral Epidemiology Branch, National Cancer Institute is initiating a new cohort and nested case-control study of cancers occurring in persons with human immunodeficiency virus (HIV) associated immunosuppression. Five thousand subjects will be recruited from AIDS treatment and clinical trial sites to be followed prospectively for cancer endpoints. Baseline data and blood samples will be collected on cancer cases. One hundred-fifty cases of non-Hodgkin's lymphoma, a similar number of cases of Kaposi's sarcoma, and approximately 45 cases of other cancers are expected over a 3 year follow-up. Data from this study will be used to identify rates and risk factors for HIV-associated malignancies. Therapies for HIV will be specifically investigated as potential risk factors. The biologic specimens will be analyzed for etiologic factors and intermediate markers for HIV-associated carcinogenesis. This study will generate a larger collection of HIV associated tumors linked with pre-cancer sera and lymphocytes than any of the current U.S. natural history cohorts. These materials will increase our ability to characterize HIV associated carcinogenesis and address basic issues regarding neoplasia.