SEQUENTIAL KIDNEY/PANCREATIC ISLET CELL TRANSPLANTATION

我们将进行总共20个连续的肾胰岛移植。 胰岛将通过门静脉经皮注入肝脏。接受者将是肾功能稳定并患有1型糖尿病的患者。 我们的研究将有助于确定最佳的候选人，免疫抑制，地点和胰岛移植的可行性。 移植前，将使用胰高血糖素激发验证C肽阴性。 在1周、1个月、3个月、6个月和1-5年的每年，将使用sustacal膳食激发试验评估胰岛素分泌。

We will perform a total of 20 sequential kidney islet transplants. The islets will be injected percutaneously into the liver via the portal vein. The recipients will be patients who have a stable functioning kidney and have type 1 diabetes. Our research will help define the optimal candidates, immunosuppression, site, and feasibility of pancreatic islet transplantation. Prior to transplantation, C-peptide negativity will be verified using a glucagon challenge. At 1 week, 1 month, 3 months, 6 months, and yearly from 1-5 years, insulin secretion will be assessed using a sustacal meal challenge test.