PCO MEASUREMENT OF RAS PROTEIN IN PCOS

多囊卵巢综合征（PCOS）高胰岛素血症患者与正常女性相比，法尼基化RAS蛋白表达增加。 大鼠肉瘤（RAS）是一种与细胞增殖状态（如增生和瘤形成）相关的细胞内蛋白。 在PCOS中，卵巢的特征在于增殖性变化，例如多个大囊肿形成、卵泡膜细胞增生、髓质基质增加、囊增厚和普遍增大。 PCOS患者也是高胰岛素血症。 本研究旨在确定法尼基化RAS蛋白的表达是否与该疾病的临床特征相关。

Hyperinsulinemic patients with polycystic ovary syndrome (PCOS) exhibit a greater expression of farnesylated RAS protein compared to that of normal women. Rat sarcoma (RAS) is an intracellular protein which is associated with cellular proliferative states such as hyperplasia and neoplasia. In PCOS the ovary is characterized by proliferative changes such as multiple large cyst formation, theca cell hyperplasia, an increase in medullary stroma, a thickened capsule and general enlargement. PCOS patients are also hyperinsulinemic. This study wishes to determine whether the expression of farnesylated RAS protein is correlated to clinical features of this disorder.