HMG COA REDUCTASE

3-羟基-3-甲基戊二酰辅酶A还原酶(HMG-CoA 还原酶)催化生物合成中的承诺步骤 异戊二烯和类固醇，如维生素D和胆固醇。HMG-CoA 还原酶是抑制剂的靶点，是目前临床应用的首选药物。 降胆固醇药物。我们得到了很好的衍射光 人HMG-CoS还原酶催化结构域的结晶。虽然 哺乳动物HMG-CoA还原酶同源物的结构 梅瓦隆假单胞菌已被破解，序列与人类同源性 还原酶只有20%，分子置换液还没有 已经找到了。我们打算使用硒蛋氨酸收集MAD数据 晶体有助于解决人类催化结构域的结构 HMG-CoA还原酶。

3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) catalyzes the committed step in the biosynthesis of isoprenoids and steroids such as vitamin D and cholesterol. HMG-CoA reductase is the target of inhibitors, which present a first choice in cholesterol lowering medication. We have obtained well diffracting crystals of the catalytic domain of human HMG-CoS reductase. Although the structure of a homolog to mammalian HMG-CoA reductase from Pseudomonas mevalonii has been solved, the sequence identity to human reductase is only 20% and a molecular replacement solution has not yet been found. We intend to collect MAD data using seleno-methionine crystals to help solve the structure of the catalytic domain of human HMG-CoA reductase.