Development of Oral Natriuretic-like Peptides for Chronic Treatment of Congestive Heart Failure

充血性心力衰竭是一种致命的疾病，也是影响近50万澳大利亚人的主要疾病负担。目前的治疗方法不充分，在延长生命方面非常有限。我们试图利用注射给药的人B型利钠肽的有效性，开发一种新的肽疗法。我们的目标是基于蛇毒中发现的肽产生一种口服活性和有效的治疗方法。该计划包括在动物和细胞中进行测试

Congestive heart failure is fatal disease and a major disease burdon for the community affecting nearly half a million Australians.. Current therapies are inadequate and very limited in prolonging life. We seek to develop a new peptide therepy based on the effectivness of human B type natriuetic peptide which has to be given by injection. Our aim is to produce an orally active and effective treatment based on peptides discovered in snake venom. The program involves testing in animals and cells