CRYSTAL STRUCTURE OF VISUAL ARRESTIN

G蛋白偶联受体系统是普遍存在的信号 存在于许多高等生物中的转导系统。胞外 信号通过7号信号在细胞膜上传递 激活G蛋白的跨膜受体蛋白，启动 一系列复杂的生化事件。此激活过程是 受一种名为拦阻蛋白的蛋白质家族的下调 与激活的受体结合，防止G蛋白激活。 阻滞素似乎是受体的接头分子 质膜的内化作用。我们计划收集一份 完整的原始数据集以及潜在的重原子衍生品。

G-protein coupled receptor systems are ubiquitous signal transduction systems found in many higher organisms. Extracellular signals are transmitted across the cell membrane via a seven transmembrane receptor protein which activates G-proteins, initiating a complex biochemical cascade of events. This activation process is down regulated by a growing family of proteins called arrestins which bind to the activated receptor and prevent G-protein activation. Arrestins appear to serve as adaptor molecules for receptor internalization from the plasma membrane. We plan to collect a complete native data set as well as potential heavy atom derivatives.