STRUCTURE DETERMINATION OF GLYCOHORMONES & OLIGOSACCHARIDE RELEASING ENZYMES

卵泡刺激素（FSH）是一种糖蛋白激素， 在生育中起着重要作用。 人类的晶体学研究 FSH的目的是确定负责的分子特征 受体结合和信号转导， 结构数据和定点诱变结果。 远藤A是 一种内切糖苷酶，一种从葡萄糖中释放寡糖的酶， 糖蛋白，这是独特的，因为它的转糖基化 特性. Endo A的结构表征将提供 对酶功能的重要见解， 进一步开发酶作为生产 新糖缀合物。

Follicle stimulating hormone (FSH) is a glycoprotein hormone that plays a major role in fertility. Crystallographic studies of human FSH are aimed at identifying molecular features that are responsible for receptor binding and signal transduction by correlating the structural data with results of site directed mutagenesis. Endo A is an endoglycosidase, an enzyme that releases oligosaccharides from glycoproteins, that is unique because of its transglycosylation properties. Structural characterization of Endo A will provide important insights in the function of the enzyme that will lead to further development of the enzyme as a tool for the production of neoglycoconjugates.