MICA: [18F]LW223: a superior TSPO PET radiotracer for a clinical breakthrough to detect regional tissue inflammation

该项目将研究一种新的扫描患者工具的效用，该工具将使医生更好地了解疾病是如何开始和演变的，以及如何更好地治疗他们的患者。这一新工具基于一种被称为正电子发射断层扫描或PET的高度专业化的扫描技术。这项技术允许通过向患者体内注射少量物质来研究人体内发生的不同过程。这种物质被称为放射性示踪剂，注射后，它在患者的血液中传播，到达体内的靶点，并发出信号，可以使用非常灵敏的相机在患者体外检测到。我们的新放射性示踪剂，我们将其命名为LW223，旨在使其能够靶向体内的炎症。在这个项目中，我们将随着时间的推移跟踪人体内的LW223信号。我们将在健康条件下和心脏病发作后进行这些跟踪研究，以确认这一信号代表组织炎症。

This project will study the utility of a new tool for scanning patients that will allow doctors to better understand how diseases start and evolve as well as how to better treat their patients. This new tool is based on a highly specialized scanning technique called positron emission tomography or PET. This technique allows for the study of different processes happening inside the human body by injecting a small amount of a substance into patients. That substance is called a radiotracer and after injection it travels in the patients' blood stream, reaches the target inside the body and emits a signal that can be detected outside the patients' body using a very sensitive camera. Our new radiotracer, that we named LW223, was designed so it can target inflammation inside the body. In this project we will be tracking LW223 signal inside the human body over time. We will do those tracking studies both in healthy conditions and post-heart attack to confirm this signal represents tissue inflammation.