DEVELOPMENT OF SURFACE COIL RESONATORS FOR IN VIVO L BAND

氧敏感EPR材料的优点之一是 它们可以被植入组织中，用于监测氧合。 从几天到几周。这种长期实验的一个困难是 (或在患者体内植入)，是不是精确的局部 材料不是立即明显的。为了克服这一点 问题，我们正在评估非侵入性磁共振成像的使用 EPR植入物的定位方法。所有EPR材料 到目前为止所研究的具有磁敏性的物质使它们看起来 梯度回波磁共振图像为黑色。相反，使用成像协议 其使易感效应(短TE自旋回波序列)最小化， 该材质的可见度最低。在这个项目中，我们正在优化 用于增加或降低能见度的成像参数 无创性磁共振检查中的EPR材料。

One of the strengths of oxygen sensitive EPR materials, is that they can be implanted into tissues for use in monitoring oxygenation over days to weeks. One difficulty with such long term experiments (or with implanting in patients), is that the precise local of the material is not immediately evident. In order to overcome this problem, we are assessing the use of non-invasive MR imaging as a method of localizing the EPR implants. All of the EPR materials studied to date have a magnetic susceptability which makes them appear dark on gradient echo MR images. Conversely, with imaging protocols which minimize susceptability effects (short TE spin echo sequences), the material is minimally visible. In this project, we are optimizing imaging paramaters for either increasing or reducing the visibility of EPR materials in non-invasive MR exams.