PARASITE CYTOADHERENCE MECHANISM IN MATERNAL MALARIA

合成了两类化合物：（1）三萜， (2)吲哚和相关杂环化合物。 三萜类化合物是一种 从角鲨烯衍生的一类植物五环天然产物 环化反应 我们已经开始了一项计划，修改两个共同的成员， 这类，熊果酸和油酸，在寻找新的 生物活性 在过去的一年里，我们已经合成了近 这些三萜类化合物的100个衍生物和我们迄今的结果 表明了四种不同的重要生物活性，包括 防癌、抗炎。 因此在 结构-活性研究，几种合成的三萜类化合物揭示了 显著抑制一氧化氮合成（NOS）诱导的 γ-干扰素或LPS。 一组不同的 三萜类化合物诱导HL-60白血病细胞分化。 在 此外，最近还发现了合成三萜类化合物的第三个亚组， 被发现在抑制前列腺癌的生长方面具有活性 无细胞毒性。 最后，这些小说中的一些 三萜类化合物抑制人肿瘤细胞系中的环氧合酶-2。 对于所有这些新化合物，质谱分析是必不可少的。 特征化工具。

Two classes of compounds are being synthesized (1) triterpenes and (2) indoles andrelated heterocycles. Triterpenoids eonstitute a large group of plant pentacyclic natural products derived from squalene cyclization. We have begun a program to modify two common members of this class, ursolic and oleanolic acid, in a search for novel biological activity. Over the past year, we have synthesized nearly 100 derivatives of these triterpenoids and our results to date indicate four distinct significant biological activities, including cancer chernoprevention and anti-inflammation. Thus, in a structure-activity study, several synthetic triterpenoids reveal a marked inhibition of nitric oxide synthesis (NOS) induced by gamma-interferon or LPS in mouse macrophages. A different set of triterpenoids induces differentiation of HL-60 leukemia cells. In addition, a third sub-group of synthetic triterpenoids has recently been found to be active in suppressing the growth of prostate cancer cells, without cytotoxicity. Finally, some of these novel triterpenoids inhibit cyclooxygenase-2 in a human tumor cell line. For all these new compounds, mass spectrometry is an essential characterization tool.