IN VIVO 1H SPECTROSCOPY OF HEAD & NECK TUMORS: PO2 HISTOGRAPH MEASUREMENTS

目的：对短T2的软骨进行详细检查 软骨/骨骼界面附近的松弛时间可以提供 准确测量软骨厚度和有关信息 胶原蛋白纤维组织。这一信息可能在 正常软骨结构、损伤和软骨细胞的评价 移植。我们已经开发出了一种高分辨率短视频的方法 软骨的回波时间光谱成像。材料和方法： 短回波时间光谱成像序列使用 半脉冲(TE 0.2ms)或常规激励(TE 1.6ms)。 激励之后立即进行投影重建 读出渐变。最小视场为6厘米，具有面内分辨率 117微米。切片厚度为2-3 mm，扫描时间为 4.5到9分钟。光谱分辨率为1.0ppm，光谱 带宽为6.7ppm。33兆字节数据集的重建 在太阳超音速跑车上只需4分钟。所有成像都是在1.5T上完成的 GE Signa与回声速度渐变。结果：10名正常志愿者 对四名接受软骨移植的患者进行了研究。 正常软骨表现为线条宽度增加，峰值面积减小 当从关节表面向骨骼移动时。 光谱成像解决了化学位移伪影，并且短的 回声时间可以评估钙化区的软骨 在骨皮质附近。结论：高分辨率光谱分析 关节软骨的成像可以在全身进行 扫描仪。这项技术可能会产生关于 存在胶原纤维的组织和类型。这也许是可能的 为了跟踪软骨细胞移植的发展和整合， 并区分纤维软骨和透明软骨 移植地点。

Purpose: Detailed examination of cartilage with short T2 relaxation times near the cartilage/bone interface may provide accurate measurements of cartilage thickness and information about collagen fiber organization. This information could be important in assessment of normal cartilage structure, injury and chondrocyte transplants. We have developed a method for high resolution short echo time spectroscopic imaging of cartilage. Materials and Methods: The short echo time spectroscopic imaging sequence uses either a half-pulse (TE 0.2 ms) or conventional excitation (TE 1.6 ms). Excitation is followed immediately by projection reconstruction readout gradients. Minimum FOV is 6 cm, with an in-plane resolution of 117 micrometers. Slice thickness is 2-3 mm, and scan time is from 4.5 to 9 minutes. Spectral resolution is 1.0 ppm, and spectral bandwidth is 6.7 ppm. Reconstruction of the 33 megabyte data set takes 4 minutes on a Sun Ultrasparc. All imaging was done on a 1.5T GE Signa with Echospeed gradients. Results: Ten normal volunteers and four patients with cartilage transplants have been studied. Normal cartilage shows increasing line width and decreasing peak area when moving from the articular surface towards the bone. Spectroscopic imaging resolves chemical shift artifact, and the short echo time allows evaluation of the cartilage in the calcified zone near the bony cortex. Conclusion: High resolution spectroscopic imaging of articular cartilage can be performed on a whole-body scanner. This technique may yield new information about the organization and type of collagen fibers present. It may be possible to follow the development and integration of chondrocyte transplants, and distinguish fibrocartilage from hyaline cartilage at the transplant site.