MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMEN

描述 （改编自申请人摘要）本临床试验的目的 研究者发展奖是准备候选人，博士克莉丝汀 阿尔伯特医学博士，作为心血管疾病的独立研究者 特别强调预防和治疗 心律失常 阿尔伯特博士对 心源性猝死（SCD）的临床综合征， 室性心律失常 申请人提出了一个为期5年的计划， 这项研究将前瞻性地检查SCD的特定风险因素， 男人和女人 需要检验的假设包括： 饮食因素（特别是海洋n-3脂肪酸、α-亚麻酸 酸，镁，酒精和抗氧化剂），性激素和阿司匹林 SCD的风险。 SCD的可能触发因素，包括体力活动和 焦虑，也将被检查。 在女性中，SCD尚未得到充分研究， 将进行分析以更好地定义病理生理学。 性 还将在这些分析的范围内探讨差异。 的 调查将在三个队列研究中进行：护士的 对121 700名目前年龄在50-75岁之间的妇女进行的健康研究; 1982年对22，071名40-84岁男性的研究;以及女性的抗氧化剂 对8,172名40岁及以上女性进行的心血管研究， 心血管疾病或至少三种冠状动脉危险因素。 最后一 队列研究为研究高危女性SCD提供了机会。 在计划的研究项目结束时，阿尔伯特博士将获得 先进的流行病学技能，然后可以应用于独立的 在她所选择的电生理学的子专业中进行研究。

DESCRIPTION (Adapted from applicants' abstract) The purpose of this Clinical Investigator Development Award is to prepare the candidate, Dr. Christine Albert, M.D., for a career as an independent investigator in cardiovascular epidemiology with a special emphasis on the prevention and treatment of cardiac arrhythmias. Dr. Albert has developed a great interest in the clinical syndrome of sudden cardiac death (SCD) and life-threatening ventricular arrhythmias. The applicant proposes a 5-year program of research that will prospectively examine risk factors specific for SCD in men and women. The hypotheses to be examined include: the influence of dietary factors (in particular, marine n-3 fatty acids, alpha-linolenic acid, magnesium, alcohol, and antioxidants), sex hormones, and aspirin on the risk of SCD. Possible triggers of SCD, including physical activity and anxiety, will also be examined. In women, SCD has not been well studied and analyses will be performed to better define pathophysiology. Sex differences will also be explored in the context of these analyses. The investigations will be performed in three cohort studies: the Nurses' Health Study of 121,700 women currently aged 50-75; the Physicians' Health Study of 22,071 men aged 40-84 years in 1982; and the Women's Antioxidant Cardiovascular Study of 8,172 women aged 40 and older with known cardiovascular disease or at least three coronary risk factors. The last cohort provides an opportunity to study SCD in women who are at high risk. At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology.