COLORECTAL DISEASE PREVENTION IN MULTIETHNIC POPULATION

描述：（申请人描述）拟定研究结直肠 多种族人群的疾病预防检查了家庭和 与结直肠癌相关的生活方式风险因素，以及 结直肠癌一级亲属的态度、知识和行为 癌症病例和无癌症对照受试者对原发性和继发性 预防大肠癌。 将进行干预研究 评估干预计划的有效性，以增加使用 推荐的结直肠癌早期检测程序。 研究与结直肠癌相关的家庭和生活方式危险因素， 癌症在新墨西哥州，一个基于人群的病例对照研究设计将 用于评估以下假设： 可以改变的生活方式因素，包括饮食，体育活动， 肥胖、吸烟和饮酒。 我们目前正在 进行一项病例系列研究，以检查结直肠癌的比例， 癌症病例中表现出复制错误修复表型， 人口 将添加无癌症对照受试者样本， 评估生活方式风险因素与家庭和 散发性结直肠癌 干预研究采用随机干预试验设计， 干预武器。 干预措施中包括的两个目标人群 研究对象是结直肠癌病例和对照一级亲属 科目 定性和定量数据将用于 制定基线电话调查和设计干预措施 程序. 将在3个月和12个月时进行干预评估 干预后检查推荐的结直肠癌的利用率 筛选程序。 预防肿瘤学学术奖将促进专业 候选人作为独立研究员的成长和职业发展 也是预防肿瘤学的老师 培训和研究将 由Charles Key监督，导师和合作者T.贝克尔湖 伯恩斯坦，N. Cobb，S.戴维斯，F.吉利兰角赫尔曼，D. M. Parkin，J. Potter，N. Wallerstein，D.韦德角Willman和S. Winawer

DESCRIPTION: (Applicant's Description) The proposed study Colorectal Disease Prevention in Multi-Ethnic Populations examines familial and lifestyle risk factors associated with colorectal cancer, as well as the attitude, knowledge, and behavior of first-degree relatives of colorectal cancer cases and cancer-free control subjects toward primary and secondary prevention of colorectal cancer. An intervention study will be carried out to evaluate the effectiveness of an intervention program to increase use of recommended colorectal cancer early detection procedures. To examine familial and lifestyle risk factors associated with colorectal cancer in New Mexico, a population-based case-control study design will be used to evaluate the hypothesis that colorectal cancer risk is altered by lifestyle factors that are modifiable, including diet, physical activity, obesity, cigarette smoking, and alcohol consumption. We are currently conducting a case-series study to examine the proportion of colorectal cancer cases that exhibit the replication error repair phenotype in the population. A sample of cancer-free control subjects will be added to assess the role of lifestyle risk factors associated with familial and sporadic colorectal cancers. The intervention study uses a randomized intervention trial design with two intervention arms. The two target populations included in the intervention study are first-degree relatives of colorectal cancer cases and control subjects. Qualitative and quantitative data will be used for the development of a baseline telephone survey and the design of an intervention program. Evaluation of the intervention will be done at 3 and 12 months post-intervention to examine utilization of recommended colorectal cancer screening procedures. The Preventive Oncology Academic Award will facilitate the professional growth and career development of the candidate as an independent researcher and teacher in preventive oncology. The training and research will be supervised by Charles Key, with mentors and collaborators T. Becker, L. Bernstein, N. Cobb, S. Davis, F. Gilliland, C. Herman, D.M. Parkin, J. Potter, N. Wallerstein, D. Weed, C. Willman, and S. Winawer.